Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction
Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction
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DOI：
10.1016/s1995-7645(13)60018-8
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发表时间：
2013-03-01
影响因子：
3.1
通讯作者：
Adeola, Salawu Oluwakanyinsola
中科院分区：
文献类型：
--
作者：
Ifeoma, Obidike;Samuel, Okhale;Adeola, Salawu Oluwakanyinsola
目的：研究珍珠草（P. niruri）甲醇提取物（ME）及其部位对小鼠的抗疟原虫活性。方法：对蓝藻甲醇提取物及其氯仿、乙醇和水部分进行针对氯喹敏感的伯氏疟原虫的测试。早期，分别使用 Knight 和 Peter 的 4 天抑制模型、Ryley 和 Peters 治疗模型以及 Peters 预防模型建立了感染的中库模型。结果：100-400 mg/kg（体重）的 ME 引起寄生虫血症的化学抑制（37.65%-50.53%）。在 100 mg/kg b.w. 的剂量下，氯仿分数 (F1) 显着 (P
Objective: To investigate the antiplasmodial activity of Phyllanthus niruri (P. niruri) methanol extract (ME) and its fractions in mice. Methods: P. niruri methanol extract and its chloroform, ethanol and aqueous portions were tested against chloroquine-sensitive Plasmodium berghei berghei. in early, established mid repository models of infection using Knight and Peter's 4-day suppressive model, Ryley and Peters curative model and Peters prophylactic model respectively. Results: Chemosuppression of parasitaemia (37.65%-50.53 %) was elicited by 100-400 mg/kg (b.w.) of ME. At doses of 100 mg/kg b.w., the chloroform fraction (F1) significantly (P