Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians.
Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians.
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DOI：
10.1186/s12862-021-01900-y
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发表时间：
2021-09-22
影响因子：
2.2
通讯作者：
Ohashi J
中科院分区：
文献类型：
--
作者：
Isshiki M;Naka I;Kimura R;Nishida N;Furusawa T;Natsuhara K;Yamauchi T;Nakazawa M;Ishida T;Inaoka T;Matsumura Y;Ohtsuka R;Ohashi J
在过去的几千年里，智人经历了多次混合。为了研究混合如何影响当地的适应，我们研究了现代波利尼西亚人的基因组，他们是通过东南亚讲南岛语的人（亚洲相关的祖先）和近大洋洲的土著人（巴布亚相关的祖先）之间的混合而形成的。在这项研究中，在波利尼西亚人（23名汤加受试者）的基因组中估计了当地祖先，以找到巴布亚相关祖先贡献的混合选择的候选区域。在整个波利尼西亚基因组中，巴布亚相关祖先的平均比例估计为24.6%。（SD = 8.63%），以及两个基因组区域，即6号染色体上的延伸的主要组织相容性复合体（xMHC）区域和16号染色体上的ATP结合盒转运蛋白亚家族C成员11（ABCC 11）基因，显示巴布亚相关祖先的比例比平均值高5个标准差（> 67.8%）。在选择性中性假设下的合并模拟表明，这种信号的巴布亚相关的祖先富集是由混合后的积极选择（错误发现率= 0.045）。ABCC 11含有一个非同义的SNP，rs 17822931，它影响顶浆分泌细胞的功能。近似贝叶斯计算表明，在波利尼西亚的祖先，一个强大的正选择（s = 0.0217）作用于祖先的等位基因rs 17822931来自巴布亚相关的祖先。我们的研究结果表明，混合与巴布亚相关的祖先波利尼西亚祖先的快速本地适应。考虑到人类进化史上频繁的混合事件，通过混合加速局部适应应该是人类的一个共同事件。在线版本包含补充材料，可在10.1186/s12862-021-01900-y获得。
Homo sapiens have experienced admixture many times in the last few thousand years. To examine how admixture affects local adaptation, we investigated genomes of modern Polynesians, who are shaped through admixture between Austronesian-speaking people from Southeast Asia (Asian-related ancestors) and indigenous people in Near Oceania (Papuan-related ancestors). In this study local ancestry was estimated across the genome in Polynesians (23 Tongan subjects) to find the candidate regions of admixture-enabled selection contributed by Papuan-related ancestors. The mean proportion of Papuan-related ancestry across the Polynesian genome was estimated as 24.6% (SD = 8.63%), and two genomic regions, the extended major histocompatibility complex (xMHC) region on chromosome 6 and the ATP-binding cassette transporter sub-family C member 11 (ABCC11) gene on chromosome 16, showed proportions of Papuan-related ancestry more than 5 SD greater than the mean (> 67.8%). The coalescent simulation under the assumption of selective neutrality suggested that such signals of Papuan-related ancestry enrichment were caused by positive selection after admixture (false discovery rate = 0.045). The ABCC11 harbors a nonsynonymous SNP, rs17822931, which affects apocrine secretory cell function. The approximate Bayesian computation indicated that, in Polynesian ancestors, a strong positive selection (s = 0.0217) acted on the ancestral allele of rs17822931 derived from Papuan-related ancestors. Our results suggest that admixture with Papuan-related ancestors contributed to the rapid local adaptation of Polynesian ancestors. Considering frequent admixture events in human evolution history, the acceleration of local adaptation through admixture should be a common event in humans. The online version contains supplementary material available at 10.1186/s12862-021-01900-y.
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影响因子：
64.8
作者：
Kong A;Frigge ML;Masson G;Besenbacher S;Sulem P;Magnusson G;Gudjonsson SA;Sigurdsson A;Jonasdottir A;Jonasdottir A;Wong WS;Sigurdsson G;Walters GB;Steinberg S;Helgason H;Thorleifsson G;Gudbjartsson DF;Helgason A;Magnusson OT;Thorsteinsdottir U;Stefansson K
通讯作者：
Stefansson K
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
1.8
作者：
Hogg, AG;Higham, TFG;Newnham, RM
通讯作者：
Newnham, RM
DOI：
10.1126/science.1243518
发表时间：
2014-02-14
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hellenthal G;Busby GBJ;Band G;Wilson JF;Capelli C;Falush D;Myers S
通讯作者：
Myers S
影响因子：
4.5
作者：
Johnson NA;Coram MA;Shriver MD;Romieu I;Barsh GS;London SJ;Tang H
通讯作者：
Tang H