SEX-DIFFERENCES IN PERIPHERAL VASCULAR ADRENERGIC-RECEPTORS
SEX-DIFFERENCES IN PERIPHERAL VASCULAR ADRENERGIC-RECEPTORS
复制标题
DOI：
10.1161/01.res.61.4.581
复制
发表时间：
1987-10-01
影响因子：
20.1
通讯作者：
DESAI, N
中科院分区：
文献类型：
--
作者：
FREEDMAN, RR;SABHARWAL, SC;DESAI, N
尽管许多血管疾病的发病率在男性和女性中有所不同，但血管生理学的性别差异尚未在人体体内研究中得到广泛研究。本研究比较了正常男性和女性在肱动脉输注肾上腺素能激动剂和其他神经和非神经介导的手术后手指血流反应。在对苯肾上腺素和可乐定的反应中，男性表现出明显的与剂量相关的血管收缩，而女性则没有。在异丙肾上腺素的作用下，男性表现出明显的剂量相关的血管舒张，而女性则没有。动脉内注射硝酸甘油或地高辛或反应性充血的反应没有性别差异，这些手术不通过肾上腺素能受体起作用。这些数据表明，女性外周血管肾上腺素能受体的敏感性和/或密度低于男性。对反射性血管收缩或动脉内酪胺的反应没有性别差异，表明神经释放的去甲肾上腺素在。α起作用。-肾上腺素能受体，从那些对循环的儿茶酚胺有反应的受体中分离出来。
Although the incidence of many vascular diseases differs in men and women, sex differences in vascular physiology have not been extensively examined in human in vivo studies. The present study compared finger blood flow responses of normal men and women with brachial artery infusions of adrenergic agonists and with other neurally and nonneurally mediated procedures. In response to phenylephrine and clonidine, men showed significant dose-related vasoconstriction while women did not. In response to isoproterenol, men showed significant dose-related vasodilation while women did not. There were no sex differences in response to intra-arterial nitroglycerin or digoxin or to reactive hyperemia, procedures that do not act through adrenergic receptors. These data show that the sensitivity and/or density of peripheral vascular adrenergic receptors is lower in women than in men. There were no sex differences in response to reflex vasoconstriction or to intra-arterial tyramine, suggesting that neurally released norepinephrine acts at .alpha.-adrenergic receptors that are spatially removed from those that respond to circulating cathecholamines.