CHIP as a therapeutic target for neurological diseases
CHIP as a therapeutic target for neurological diseases
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CHIP作为神经系统疾病的治疗靶点
DOI：
10.1038/s41419-020-02953-5
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发表时间：
2020-09
影响因子：
9
通讯作者：
Yuming Xu
中科院分区：
文献类型：
--
作者：
Shuo Zhang;Zhengwei Hu;Chengyuan Mao;Changhe Shi;Yuming Xu
Hsc70相互作用蛋白（CHIP）的羧基端作为分子伴侣和泛素E3连接酶在调节许多伴侣结合蛋白的降解中起关键作用。到目前为止，它已经涉及许多生物功能的调节，包括错误折叠蛋白质重折叠，自噬，免疫和坏死性凋亡。此外，CHIP在中枢神经系统中的普遍表达表明它可能涉及神经系统疾病中的广泛功能。我们实验室和其他小组最近的几项研究强调了CHIP在几种神经系统疾病发病机制中的有益作用。本文综述了CHIP基因在脑卒中、脑出血、阿尔茨海默病、帕金森病、多聚谷氨酰胺病等神经系统疾病中的作用，并探讨了CHIP基因突变可能导致神经退行性疾病的分子机制。根据现有文献，CHIP过表达可以作为多种神经系统疾病的有希望的治疗靶点。
Carboxy-terminus of Hsc70-interacting protein (CHIP) functions both as a molecular co-chaperone and ubiquitin E3 ligase playing a critical role in modulating the degradation of numerous chaperone-bound proteins. To date, it has been implicated in the regulation of numerous biological functions, including misfolded-protein refolding, autophagy, immunity, and necroptosis. Moreover, the ubiquitous expression of CHIP in the central nervous system suggests that it may be implicated in a wide range of functions in neurological diseases. Several recent studies of our laboratory and other groups have highlighted the beneficial role of CHIP in the pathogenesis of several neurological diseases. The objective of this review is to discuss the possible molecular mechanisms that contribute to the pathogenesis of neurological diseases in which CHIP has a pivotal role, such as stroke, intracerebral hemorrhage, Alzheimer’s disease, Parkinson’s disease, and polyglutamine diseases; furthermore, CHIP mutations could also cause neurodegenerative diseases. Based on the available literature, CHIP overexpression could serve as a promising therapeutic target for several neurological diseases.
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影响因子：
7.2
作者：
Selkoe, Dennis J.
通讯作者：
Selkoe, Dennis J.
影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
3.3
作者：
Takeuchi T;Nagai Y
通讯作者：
Nagai Y
影响因子：
7.8
作者：
Singh AK;Pati U
通讯作者：
Pati U
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM