Laser triggered drug release from magnetoliposomes
Laser triggered drug release from magnetoliposomes
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DOI：
10.1016/s0304-8853(98)00553-8
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发表时间：
1999-04-01
影响因子：
2.7
通讯作者：
Babinec, P
中科院分区：
文献类型：
--
作者：
Babincová, M;Sourivong, P;Babinec, P
制备磷脂酰胆碱脂质体与6-羧基荧光素和葡聚糖-磁铁矿包埋在其水性内部隔室。这种所谓的磁性脂质体系统被评估其使用激光作为药物释放的触发机制的可行性。响应于单个纳秒激光脉冲释放大量的羧基荧光素。间接地，它已被证明，这种效果可能是由于磁铁矿介导的局部温度升高。(C)1999 Elsevier Science B. V.保留所有权利。
Phosphatidylcholine liposomes were prepared with 6-carboxyfluorescein and dextran-magnetite entrapped in their aqueous interior compartments. This so-called magnetoliposome system was evaluated for its feasibility of using a laser as a triggering mechanism for the release of drugs. Substantial amounts of carboxyfluorescein were released in response to a single nanosecond laser pulse. Indirectly it has been shown that this effect is probably due to the magnetite-mediated localized temperature increase. (C) 1999 Elsevier Science B.V. All rights reserved.