BROWN ADIPOSE-TISSUE ACTIVITY IN PYREXIAL CASES OF COT DEATH
BROWN ADIPOSE-TISSUE ACTIVITY IN PYREXIAL CASES OF COT DEATH
复制标题
DOI：
10.1136/jcp.42.11.1153
复制
发表时间：
1989-11-01
影响因子：
3.4
通讯作者：
JENNINGS, G
中科院分区：
文献类型：
--
作者：
LEAN, MEJ;JENNINGS, G
对两例婴儿猝死病例的棕色脂肪组织进行了研究，这些病例的核心温度在到达停尸房时高于40摄氏度。从线粒体(8-3 H)鸟苷二磷酸(GDP)结合和主动产热与线粒体呼吸解偶联的摄氧量中获得证据，线粒体呼吸被GDP重新耦合。棕色脂肪组织的生热能力，通过负责产热的特定线粒体膜解偶联蛋白的放射免疫分析来估计，与在其他婴儿或适应中等温度条件(23摄氏度)的实验动物中测得的相似。棕色脂肪组织产热不适当地发生在温暖、隔热良好的婴儿身上，可能是导致婴儿床死亡的原因之一。
Brown adipose tissue was investigated in two cases of cot death in which core temperatures were above 40.degree.C on arrival at the mortuary. Evidence was obtained from mitochondrial (8-3H) guanosine diphosphate (GDP) binding and oxygen uptake of active thermogenesis with uncoupled mitochondrial respiration which was recoupled by GDP. Thermogenic capacity of brown adipose tissue, estimated by radioimmunoassay of the specific mitochondrial membrane "uncoupling protein" responsible for heat production, was similar to that measured in other infants or in experimental animals acclimated to moderately warm conditions (23.degree.C). Brown adipose tissue thermogenesis, occurring inappropriately in a warm, well insulated infant, could be a cause of some cases of cot death.