Cancer associated thrombosis: risk factors and outcomes
Cancer associated thrombosis: risk factors and outcomes
复制标题
DOI：
10.1016/s0049-3848(16)30092-5
复制
发表时间：
2016-04-01
影响因子：
7.5
通讯作者：
Eichinger, Sabine
中科院分区：
文献类型：
--
作者：
Eichinger, Sabine
腿部深静脉血栓和肺栓塞是常见疾病，而癌症是其最重要的危险因素之一。癌症患者在腿部和/或上肢、内脏或脑静脉等不常见部位的其他部位也有更高的静脉血栓形成发生率。癌症还会影响动脉血栓事件的风险，尤其是骨髓增生性肿瘤患者和血管内皮生长因子受体抑制剂接受者。多种危险因素需要相互作用才能引发血栓形成。除了手术、住院、感染和遗传性凝血障碍等常见风险因素外，血栓形成风险还受到癌症特异性因素的驱动和改变，包括恶性肿瘤的类型、组织学和分期、癌症治疗和某些生物标志物。癌症患者的静脉血栓事件会带来严重后果，因为血栓复发的风险、抗凝期间出血的风险以及住院率都会增加。与没有血栓的癌症患者相比，有血栓的癌症患者的生存率较差，并且血栓是癌症患者死亡的首要直接原因。 (C) 2016 Elsevier Ltd. 保留所有权利。
Deep vein thrombosis of the leg and pulmonary embolism are frequent diseases and cancer is one of their most important risk factors. Patients with cancer also have a higher prevalence of venous thrombosis located in other parts than in the legs and/or in unusual sites including upper extremity, splanchnic or cerebral veins. Cancer also affects the risk of arterial thrombotic events particularly in patients with myeloproliferative neoplasms and in vascular endothelial growth factor receptor inhibitor recipients. Several risk factors need to interact to trigger thrombosis. In addition to common risk factors such as surgery, hospitalisation, infection and genetic coagulation disorders, the thrombotic risk is also driven and modified by cancer-specific factors including type, histology, and stage of the malignancy, cancer treatment and certain biomarkers. A venous thrombotic event in a cancer patient has serious consequences as the risk of recurrent thrombosis, the risk of bleeding during anticoagulation and hospitalisation rates are all increased. Survival of cancer patients with thrombosis is worse compared to that of cancer patients without thrombosis, and thrombosis is a leading direct cause of death in cancer patients. (C) 2016 Elsevier Ltd. All rights reserved.