Hypoglycemic effects of Tibetan medicine Huidouba in STZ-induced diabetic mice and db/db mice
Hypoglycemic effects of Tibetan medicine Huidouba in STZ-induced diabetic mice and db/db mice
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DOI：
10.1016/j.chmed.2021.02.001
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发表时间：
2021
影响因子：
3.8
通讯作者：
庞宗然
中科院分区：
文献类型：
--
作者：
白颖慧;石东旭;陆红羽;杨坤宝;赵焕虎;鲁碧楠;庞宗然
Objective: Huidouba (HDB) is a Chinese folk medicine used to treat diabetes in.Sichuan Province, China. Therefore, we investigated the anti-diabetic effects of HDB.and its underlying mechanisms. We hypothesized that HDB treatment could enhance.glucose tolerance and insulin sensitivity, and thus prevent a hyperglycemia state..Methods: To test the hypothesis, streptozotocin (STZ)-induced diabetic mice and.db/db mice, widely used models of hyperglycemia and insulin-resistant diabetes, were.either treated with HDB, metformin, or acarbose. Blood glucose, oral glucose.tolerance test, insulin tolerance test, pancreatic histopathology and serum biochemistry.were detected to assess the hypoglycemic effect of HDB..Results: HDB treatments were found to show the effect in reducing glucose levels..HDB also resulted in a significant reduction in body weight and food intake in the.STZ-induced diabetic mouse model. Furthermore, it significantly improved glucose.and insulin tolerance in the two diabetic mouse models. Importantly, insulin,.glucagon, pancreatic polypeptide, and somatostatin immunohistochemistry revealed.that HDB treatment improved the function and the location of the cells in the islets.compared with the other two treatments. HDB treatment resulted in significant.restoration of islet function. Our results illustrated the underlying mechanism of HDB.in the progression of diabetes, and HDB can be an effective agent for the treatment of.diabetes..Conclusion: The results of this study suggest that HDB can reduce blood glucose.levels in STZ-induced hyperglycemic mice and db/db mice.
