Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping
Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping
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DOI：
10.1073/pnas.0503892102
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发表时间：
2005-07-05
影响因子：
11.1
通讯作者：
Stark, C
中科院分区：
文献类型：
--
作者：
Miller, MI;Beg, MF;Stark, C
通过使用大变形微分同胚度量映射（LDDMM）来消除受试者之间的解剖差异，研究内侧颞叶（MTL）陈述性记忆任务的功能性磁共振成像反应。LDDMM用于将多个受试者的MTL结构映射到外部图谱坐标中；这些相同的微分同胚映射用于将相应的功能数据激活转移到相同的外部坐标。平均LDDMM映射信号的统计功效比传统的Talairach - Tournoux平均法显著提高。激活模式在MTL内高度局部化。虽然目前的演示旨在增强MTL内的对齐，但该技术具有通用性，可应用于整个大脑。
The functional magnetic resonance imagery responses of declarative memory tasks in the medial temporal lobe (MTL) are examined by using large deformation diffeomorphic metric mapping (LDDMM)to remove anatomical variations across subjects. LDDMM is used to map the structures of the MTL in multiple subjects into extrinsic atlas coordinates; these same diffeomorphic mappings are used to transfer the corresponding functional data activation to the same extrinsic coordinates. The statistical power in the averaged LDDMM mapped signals is significantly increased over conventional Talairach-Tournoux averaging. Activation patterns are highly localized within the MTL. Whereas the present demonstration has been aimed at enhancing alignment within the MTL, this technique is general and can be applied throughout the brain.