A Comparison of National Guidelines for Network Meta-Analysis
A Comparison of National Guidelines for Network Meta-Analysis
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DOI：
10.1016/j.jval.2014.06.001
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发表时间：
2014-07-01
期刊：
影响因子：
4.5
通讯作者：
Hawkins, Neil
中科院分区：
文献类型：
--
作者：
Laws, Andrew;Kendall, Robyn;Hawkins, Neil
目的：在技术评估中，有必要比较可能在考虑的患者组中使用的全套治疗方法。随机对照试验是这些比较的关键证据来源。网络荟萃分析技术允许对试验证据网络进行评估，以获得治疗组之间比较疗效的估计。如果没有进行直接比较感兴趣的治疗的试验，这些技术可能是估计比较有效性的唯一来源，如果存在直接和间接比较，这些技术可能提供有用的额外证据。方法：我们审查了报销和卫生技术评估机构发布的指南和指南草案，并考虑了他们的建议，使用适当的方法进行间接比较和评估其有效性。结果：审查了33个国家的指南。其中，来自澳大利亚、比利时、加拿大、法国、德国、苏格兰、西班牙、南非和英国（英格兰和威尔士）的9个国家的指南包括了关于实施网络荟萃分析的详细建议。总结了各项建议。结论：没有来自多个国家指南的两项建议是相互排斥的。可以执行一个网络元分析以提交给多个国家司法管辖区。
Objectives: Within technology appraisals, it is necessary to compare the complete set of treatments that may be used in the patient group under consideration. Randomized controlled trials are a key source of evidence for these comparisons. The techniques of network meta-analysis allow the networks of trial evidence to be evaluated to obtain estimates of comparative efficacy between sets of treatments. These techniques may be the only source of estimates of comparative effectiveness if trials directly comparing the treatments of interest have not been conducted, and may provide useful additional evidence if both direct and indirect comparisons exist. Methods: We examined both published and draft guidelines from reimbursement and health technology appraisal bodies, and considered their recommendations using appropriate methodology for the conduct of indirect comparisons and the assessments of their validity. Results: Guidelines from 33 countries were reviewed. Of these, guidelines from 9 countries-Australia, Belgium, Canada, France, Germany, Scotland, Spain, South Africa, and the United Kingdom (England and Wales)-included detailed recommendations on the conduct of network meta-analysis. The recommendations were summarized. Conclusions: No two recommendations from the multiple national guidelines are mutually exclusive. It is possible to perform one network meta analysis for submission to multiple national jurisdictions.