TRANS PROF DB: A new resource for sharing translational profiles.
TRANS PROF DB: A new resource for sharing translational profiles.
复制标题
DOI：
10.4161/2169074x.2014.965615
复制
发表时间：
2014-09-01
期刊：
影响因子：
--
通讯作者：
Willis AE
中科院分区：
文献类型：
--
作者：
Spriggs RV;Willis AE
使用翻译图谱技术可以在全基因组范围内测量单个mRNAs的翻译效率。这些实验的数据对于了解细胞状态对基因表达的影响是一个极其重要的资源。为了提高我们对这些数据的理解，我们创建了TRANS PROF DB，这是一个手动管理的资源，包含在定义的条件下人类mRNAs的翻译状态。结果是在每个基因的注释结论的水平上提供的，例如“翻译上调”，以及在可能的情况下，以粗略的形式，例如归一化分析的微阵列输出。TRANS DB教授的目标是为共享翻译配置文件提供一个中央资源，以促进已发布数据的重复使用，并实现跨数据集的元分析。随着数据库的扩大，它将提供一个公共可用的翻译概况数据集的易于搜索的档案。我们鼓励所有研究人员将他们的翻译概况数据存储到TRANS教授DB中，以使我们能够创建真正全面的资源。TRANS PROF DB可在mrctools.mrctox.le.ac.uk/TRANS_PROF_DB上无限制地获得。
The translational efficiency of individual mRNAs can be measured on a genome-wide scale using translational profiling techniques. Data from such experiments are an enormously important resource in the quest to understand the impact of cellular state on gene expression. To improve our understanding of these data, we have created TRANS PROF DB, a manually curated resource containing the translational status of human mRNAs under defined conditions. Results are provided at the level of an annotated conclusion for each gene, e.g. “Translation up-regulated”, and also, where available, in a rawer form such as the normalized analyzed microarray output. TRANS PROF DB aims to provide a central resource for the sharing of translational profiles to facilitate reuse of published data and to enable meta-analyses across data sets. As the database expands, it will provide an easily searchable archive of publicly available translational profiling data sets. We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource. TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.