Prognostic significance of p27KIP1 expression in resected non-small cell lung cancers:: Analysis in combination with expressions of p16INK4A, pRB, and p53
Prognostic significance of p27KIP1 expression in resected non-small cell lung cancers:: Analysis in combination with expressions of p16INK4A, pRB, and p53
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DOI：
10.1002/jso.10176
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发表时间：
2002-12-01
影响因子：
2.5
通讯作者：
Matsuda, H
中科院分区：
文献类型：
--
作者：
Hirabayashi, H;Ohta, M;Matsuda, H
背景和目的：肿瘤抑制基因(TSG)产物的表达在切除的非小细胞肺癌(NSCLC)中是否具有预后作用仍存在争议。方法：采用免疫组织化学方法检测108例非小细胞肺癌中调控细胞周期变化的p27(KIP1)、p16(INK4A)、pRb和P53蛋白的表达，并与患者的临床特征和预后进行比较。结果：在108例NSCLC中，p27(KIP1)、p16(INK4A)、pRb和P53的异常表达分别为57.00%、53(49%)、42(39%)和48(44%)。单因素分析显示，p27(KIP1)的异常表达不仅在总队列中(P=0.0024)，而且在T1-T2(P=0.016)、NO(P=0.047)和鳞癌(P=0.026)亚组中也是患者生存不良的一个强有力的指标，但与p16(INK4A)、pRb或P53的表达无关。在COX回归分析中，p27(KIP1)的表达是一个独立的预后因素(P=0.0148)，并与病理分期有关(P=0.0278)。结论：p27(KIP1)的异常表达可能是预测术后预后的有用指标，尤其是在早期非小细胞肺癌患者。
Background and Objectives: Whether a prognostic role for expression of the tumor suppressor gene (TSG) products exists in resected non-small call lung cancers (NSCLCs) remains controversial. Our study was performed to determine the value of TSGs expressions for patients survival in NSCLCs.Methods: We examined 108 resected NSCLCs for the expression of TSG products, p27(KIP1), p16(INK4A), pRB, and p53 that govern cell cycle transition by immunohistochemistry and compared them with patient clinical characteristics and prognoses.Results: Abnormal expressions of p27(KIP1), p16(INK4A), pRB, and p53 were found in 61 (57%), 53 (49%), 42 (39%), and 48 (44%), respectively, of the 108 NSCLCs. Univariate analysis showed abnormal expression of p27(KIP1) to be a strong indicator for poor patient survival, not only in the total cohort (P = 0.0024), but also in subgroups with T1-T2 (P = 0.016), NO (P = 0.047), and squamous cell carcinomas (P = 0.026), but not according to the expression of p16(INK4A), pRB, or p53. In the Cox regression analysis, p27(KIP1) expression was found to be an independent prognostic factor (P = 0.0148) and associated with pathological stage (P = 0.0278).Conclusions: Our results suggest that abnormal p27(KIP1) expression may be a useful indicator to predict postoperative prognosis, especially in patients with early stage NSCLCs, as compared to other TSG products examined.