AN INVESTIGATION OF OLIGOPEPTIDES LINKING DOMAINS IN PROTEIN TERTIARY STRUCTURES AND POSSIBLE CANDIDATES FOR GENERAL GENE FUSION
AN INVESTIGATION OF OLIGOPEPTIDES LINKING DOMAINS IN PROTEIN TERTIARY STRUCTURES AND POSSIBLE CANDIDATES FOR GENERAL GENE FUSION
复制标题
DOI：
10.1016/0022-2836(90)90085-z
复制
发表时间：
1990-02-20
影响因子：
5.6
通讯作者：
ARGOS, P
中科院分区：
文献类型：
--
作者：
ARGOS, P
从Brookhaven三维蛋白质结构数据库中提取了51个连接蛋白质结构域的寡肽。总的来说，肽在组成、构象、氢键、柔韧性等方面表现出特定的特征。然后在整个数据库中搜索可以优化这些天然连接体特性的五肽。发现的寡肽被认为是通过基因融合连接蛋白质分子或结构域的一般候选者。
Fifty-one examples of oligopeptides linking protein domains were extracted from the Brookhaven database of three-dimensional protein structures. In general, the peptides displayed specific characteristics in composition, conformation, hydrogen bonding, flexibility and the like. The entire database was then searched for pentapeptides that would optimize these natural linker properties. The oligopeptides found are suggested as general candidates to link protein molecules or domains through gene fusion.