Spatial Structure, Transmission Modes and the Evolution of Viral Exploitation Strategies
Spatial Structure, Transmission Modes and the Evolution of Viral Exploitation Strategies
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DOI：
10.1371/journal.ppat.1004810
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发表时间：
2015-04-01
期刊：
影响因子：
6.7
通讯作者：
Gandon, Sylvain
中科院分区：
文献类型：
--
作者：
Berngruber, Thomas W.;Lion, Sebastien;Gandon, Sylvain
空间结构和局部迁移被预测为促进水平传播病原体中侵袭性较低的宿主利用策略的进化。在这里，我们探索空间结构对病原体进化的影响，病原体既可以使用水平传播途径，也可以使用垂直传播途径。首先，我们从理论上分析了垂直传播如何改变进化轨迹，并证实空间可以阻止致命病原体的传播。其次，我们使用潜伏噬菌体来检验这一预测。它在大肠杆菌种群中水平和垂直传播。我们证明了潜伏噬菌体。在空间结构流行病中赢得了与剧毒突变株lambda cI857的竞争，但在空间结构受到侵蚀时输了。噬菌体的垂直传播。使其本地宿主池免受重叠感染，并防止毒力强的lambda cI857的传播。当混合促进水平传播给未受感染的宿主时，这种影响就会被打破。因此，我们确认空间结构对于在潜伏病毒中谨慎感染策略的进化维持的重要性。
Spatial structure and local migration are predicted to promote the evolution of less aggressive host exploitation strategies in horizontally transmitted pathogens. Here we explore the effect of spatial structure on the evolution of pathogens that can use both horizontal and vertical routes of transmission. First, we analyse theoretically how vertical transmission can alter evolutionary trajectories and confirm that space can impede the spread of virulent pathogens. Second, we test this prediction using the latent phage. which transmits horizontally and vertically in Escherichia coli populations. We show that the latent phage. wins competition against the virulent mutant lambda cI857 in spatially structured epidemics, but loses when spatial structure is eroded. The vertical transmission of phage. immunizes its local host pool against superinfection and prevents the spread of the virulent lambda cI857. This effect breaks down when mixing facilitates horizontal transmission to uninfected hosts. We thus confirm the importance of spatial structure for the evolutionary maintenance of prudent infection strategies in latent viruses.