Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011.
Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011.
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DOI：
10.3390/ijerph121012110
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发表时间：
2015-09-25
影响因子：
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通讯作者：
Lupo PJ
中科院分区：
文献类型：
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作者：
Peckham EC;Scheurer ME;Danysh HE;Lubega J;Langlois PH;Lupo PJ
人们有必要对评估住宅氡暴露与儿童癌症风险之间的关联感兴趣。我们试图评估德克萨斯州住宅氡暴露与儿童淋巴瘤发病率之间的关联。德克萨斯州癌症登记处 (n = 2147) 提供了 1995 年至 2011 年期间的病例信息。分母数据来自美国人口普查。区域算术平均氡气浓度是从德克萨斯州室内氡气调查中获得的，并与诊断时的居住地相关联。暴露情况进行分类评估：≤25%（参考）、>25%至≤50%、>50%至≤75%以及>75%。负二项式回归生成调整后的发生率比 (aIRR) 和 95% 置信区间 (CI)。我们对淋巴瘤进行了总体评估和亚型评估：霍奇金淋巴瘤（HL；n = 1248）、非霍奇金淋巴瘤（不包括 Burkitt）（非 BL NHL；n = 658）、Burkitt（BL；n = 241）和弥漫性大 B 细胞（DLBCL；n = 315）。没有证据表明住宅氡暴露与总体淋巴瘤、HL 或 BL 呈正相关。氡浓度 > 75% 的地区，DLBCL 发病率略有增加（aIRR = 1.73，95% CI：1.03–2.91）。在一项关于住宅氡暴露与儿童淋巴瘤发病率的最大研究中，我们发现几乎没有证据表明存在正相关或负相关。与以前的研究一致的观察结果。
There is warranted interest in assessing the association between residential radon exposure and the risk of childhood cancer. We sought to evaluate the association between residential radon exposure and the incidence of childhood lymphoma in Texas. The Texas Cancer Registry (n = 2147) provided case information for the period 1995–2011. Denominator data were obtained from the United States Census. Regional arithmetic mean radon concentrations were obtained from the Texas Indoor Radon Survey and linked to residence at diagnosis. Exposure was assessed categorically: ≤25th percentile (reference), >25th to ≤50th percentile, >50th to ≤75th percentile, and >75th percentile. Negative binomial regression generated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI). We evaluated lymphoma overall and by subtype: Hodgkin (HL; n = 1248), Non-Hodgkin excluding Burkitt (non-BL NHL; n = 658), Burkitt (BL; n = 241), and Diffuse Large B-cell (DLBCL; n = 315). There was no evidence that residential radon exposure was positively associated with lymphoma overall, HL, or BL. Areas with radon concentrations >75th percentile had a marginal increase in DLBCL incidence (aIRR = 1.73, 95% CI: 1.03–2.91). In one of the largest studies of residential radon exposure and the incidence of childhood lymphoma, we found little evidence to suggest a positive or negative association; an observation consistent with previous studies.