Essential tremor: a neurodegenerative disease?
Essential tremor: a neurodegenerative disease?
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DOI：
10.7916/d8765cg0
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Benito-León J
中科院分区：
文献类型：
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作者：
Benito-León J
特发性震颤（ET）是成人中最常见的神经系统疾病之一，也是众多震颤疾病中最常见的一种。它传统上被视为一种良性的单一症状疾病，但在过去的十年中，越来越多的证据表明 ET 是一种临床异质性的进展性疾病，因为它可能与一系列临床特征相关，包括运动和非运动因素。在这篇综述中，我将描述研究中最重要的新兴里程碑，将这些里程碑放在一起，表明 ET 是一种神经退行性疾病。 2014 年 6 月进行的一项 PubMed 搜索，涉及术语“特发性震颤”(ET) 和“神经退行性”，共找到 122 个条目，其中 20 个条目的文章标题中包含术语“神经退行性”。作者文件中与该主题相关的文章对此进行了补充。关于 ET 是否是一种神经退行性疾病，医学界正在进行公开而活跃的对话，并有大量证据支持这一点。具体来说，ET 是一种进行性衰老疾病，与神经元损失（浦肯野细胞减少）以及传统神经退行性疾病中发生的其他死后变化相关。与此同时，先进的神经影像技术现在证明了 ET 患者明显的结构变化，其中一些与神经元损失一致。然而，需要进一步的纵向临床和神经影像学纵向研究来评估进展。
Essential tremor (ET) is one of the most common neurological disorders among adults, and is the most common of the many tremor disorders. It has classically been viewed as a benign monosymptomatic condition, yet over the past decade, a growing body of evidence indicates that ET is a progressive condition that is clinically heterogeneous, as it may be associated with a spectrum of clinical features, with both motor and non-motor elements. In this review, I will describe the most significant emerging milestones in research which, when taken together, suggest that ET is a neurodegenerative condition. A PubMed search conducted in June 2014 crossing the terms “essential tremor” (ET) and “neurodegenerative” yielded 122 entries, 20 of which included the term “neurodegenerative” in the article title. This was supplemented by articles in the author's files that pertained to this topic. There is an open and active dialogue in the medical community as to whether ET is a neurodegenerative disease, with considerable evidence in favor of this. Specifically, ET is a progressive disorder of aging associated with neuronal loss (reduction in Purkinje cells) as well as other post-mortem changes that occur in traditional neurodegenerative disorders. Along with this, advanced neuroimaging techniques are now demonstrating distinct structural changes, several of which are consistent with neuronal loss, in patients with ET. However, further longitudinal clinical and neuroimaging longitudinal studies to assess progression are required.