Blood arsenic as a biomarker of arsenic exposure: Results from a prospective study
Blood arsenic as a biomarker of arsenic exposure: Results from a prospective study
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DOI：
10.1016/j.tox.2006.06.010
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发表时间：
2006-08-15
期刊：
影响因子：
4.5
通讯作者：
Graziano, Joseph
中科院分区：
文献类型：
--
作者：
Hall, Marni;Chen, Yu;Graziano, Joseph
暴露于砷（As）污染的饮用水影响着全世界数百万人。砷暴露与皮肤损伤、皮肤癌、肺癌、肾癌和肝癌、神经系统和心血管影响有关。过去的研究涉及生物标志物的砷暴露通常检查尿砷（UA）（调整尿肌酐），头发或趾甲砷，但没有血砷（BA），因为血液浓度非常低，不能检测到的常规原子吸收分光光度技术。在孟加拉国Araihazar的纵向研究（HEALS）的健康影响的8092名参与者中随机选择了303例新诊断的皮肤病变病例和849名子队列成员，在病例队列分析中，我们测量了血液，尿液和水的As浓度，并检查了它们之间的关联，以及皮肤病变的风险。BAs浓度与肌酐调整的UAs浓度（r=0.85）和水As（WAs）（r=0.75）高度相关。我们观察到一致的剂量反应关系之间的皮肤病变的风险和所有措施的作为曝光。率比（RR）的皮肤病变的五分之一的砷暴露，调整年龄和性别，揭示了两个最高的五分之一是显着相关的皮肤病变的风险增加的每一个措施的暴露：BA，UA，WA和时间加权水作为变量。这项前瞻性研究证实了皮肤病变的风险增加与血液，尿液和水中的As浓度有关，并确定了BAs是本研究人群中As暴露的有用生物标志物。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Exposure to arsenic (As)-contaminated drinking water affects millions of people worldwide. Arsenic exposure is associated with skin lesions, skin, lung, kidney and liver cancers, neurologic and cardiovascular effects. Past studies involving biomarkers of As exposure have typically examined urinary As (UAs) (adjusted for urinary creatinine), hair or toenail As, but not blood As (BAs) since blood concentrations are exceedingly low and are not detectable by conventional atomic absorption spectrophotometric techniques. In a case-cohort analysis of 303 newly diagnosed cases of skin lesions, and 849 subcohort members randomly selected from 8092 participants in the health effects of as longitudinal study (HEALS) in Araihazar, Bangladesh, we measured blood, urine and water As concentrations, and examined their associations with each other, and with the risk for skin lesions. BAs concentrations were highly correlated with creatinine-adjusted UAs concentrations (r=0.85) and with water As (WAs) (r=0.75). We observed consistent dose-response relationships between the risk of skin lesions and all the measures of As exposure. Rate ratios (RRs) for skin lesions by quintile of As exposure, adjusted for age and gender, revealed that the two highest quintiles were significantly related to an increased risk of skin lesions for each measure of exposure: BAs, UAs, WAs and a time-weighted water As variable. This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population. (c) 2006 Elsevier Ireland Ltd. All rights reserved.