Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T
Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T
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DOI：
10.1148/radiol.2016152629
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发表时间：
2016-11-01
期刊：
影响因子：
19.7
通讯作者：
Rodgers, Christopher T.
中科院分区：
文献类型：
--
作者：
Stoll, Victoria M.;Clarke, William T.;Rodgers, Christopher T.
目的：为了测试是否增加的信噪比磷31（31 P）磁共振（MR）波谱在7 T提高心脏代谢物定量扩张型心肌病（DCM）患者相比，在3 T。材料和方法：获得伦理批准，参与者提供书面知情同意。在一项前瞻性研究中，对25例DCM患者在3 T和7 T下进行了31 P MR波谱分析。10名健康对照者在7 T下进行31 P MR波谱分析。结果：与3 T相比，7 T时的磷酸肌酸（PCr）信噪比提高了2.5倍。正如预期，两种场强下的PCr与三磷酸腺苷（ATP）浓度比（PCr/ATP）相似（平均值6标准差，3 T时为1.48 +/- 0.44，7 T时为1.54 +/- 0.39，P = 0.49）。PCr浓度的Cramer-Rao下限（测量比值的不确定性）在7 T下比3 T下低45%，反映了7-T 31 P光谱的质量更高。扩张型心肌病患者在7 T时PCr/ATP明显低于健康对照组（1.54 +/- 0.39 vs 1.95 +/- 0.25，P = 0.005），这与之前的研究结果一致。7-T心脏31 P MR波谱在DCM患者中是可行的，并且提供了更高的信噪比和更精确的PCr/ATP含量高于3 T.在7 T下，DCM患者的PCr/ATP显著低于对照受试者，这与先前在较低场强下的结果一致。
Purpose: To test whether the increased signal-to-noise ratio of phosphorus 31 (31P) magnetic resonance (MR) spectroscopy at 7 T improves precision in cardiac metabolite quantification in patients with dilated cardiomyopathy (DCM) compared with that at 3 T.Materials and Methods: Ethical approval was obtained, and participants provided written informe consent. In a prospective study, 31P MR spectroscopy was performed at 3 T and 7 T in 25 patients with DCM. Ten healthy matched control subjects underwent 31P MR spectroscopy at 7 T. Paired Student t tests were performed to compare results between the 3-T and 7-T studies.Results: The phosphocreatine (PCr) signal-to-noise ratio increased 2.5 times at 7 T compared with that at 3 T. The PCr to adenosine triphosphate (ATP) concentration ratio (PCr/ATP) was similar at both field strengths (mean 6 standard deviation, 1.48 +/- 0.44 at 3 T vs 1.54 +/- 0.39 at 7 T, P = .49), as expected. The Cramer-Rao lower bounds in PCr concentration (a measure of uncertainty in the measured ratio) were 45% lower at 7 T than at 3 T, reflecting the higher quality of 7-T 31P spectra. Patients with dilated cardioyopathy had a significantly lower PCr/ATP than did healthy control subjects at 7 T (1.54 +/- 0.39 vs 1.95 +/- 0.25, P = .005), which is consistent with previous findings.Conclusion: 7-T cardiac 31P MR spectroscopy is feasible in patients with DCM and gives higher signal-to-noise ratios and more precise quantification of the PCr/ATP than that at 3 T. PCr/ATP was significantly lower in patients with DCM than in control subjects at 7 T, which is consistent with previous findings at lower field strengths.