Metabolic Adjustments by LncRNAs in Peripheral Neutrophils Partly Account for the Complete Compensation of Asymptomatic MMD Patients
Metabolic Adjustments by LncRNAs in Peripheral Neutrophils Partly Account for the Complete Compensation of Asymptomatic MMD Patients
复制标题
外周中性粒细胞中 LncRNA 的代谢调整部分解释了无症状 MMD 患者的完全代偿
DOI：
10.2174/1871527319666200618150827
复制
发表时间：
2020-01-01
影响因子：
3
通讯作者：
Luo, Yumin
中科院分区：
文献类型：
--
作者：
Han, Ziping;Li, Lingzhi;Luo, Yumin
背景：由于近期无创检查技术的发展，无症状的烟雾病（MMD）患者确诊数量较以往增多。然而，其潜在分子机制及临床干预指南仍不明确。
方法：采用微阵列技术探究无症状MMD患者外周血中性粒细胞中差异表达的信使核糖核酸（mRNA）和长链非编码核糖核酸（lncRNA）。随后，基于基因本体论（GO）和京都基因与基因组百科全书（KEGG）对这些差异表达的mRNA以及与lncRNA相关的mRNA进行富集分析，以探究潜在分子机制。
结果：在此，我们共鉴定出2824个差异表达的lncRNA和522个差异表达的mRNA（倍数变化>2且P （此处P值相关内容似乎不完整）
Background: Due to the recent development of non-invasive examinations, more asymptomatic patients with Moyamoya Disease (MMD) have been diagnosed than ever. However, its underlying molecular mechanisms and clinical intervention guidelines are all still obscure.Methods: Microarray was used to explore those differentially expressed mRNAs and lncRNAs in peripheral neutrophils of asymptomatic MMD patients. Then enrichment analyses based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) for those differentially expressed mRNAs and lncRNA associated mRNAs were performed for underlying molecular mechanisms.Results: Here, we identified a total of 2824 differentially expressed lncRNAs and 522 differentially expressed mRNAs (fold change > 2 and P