CHILDHOOD LEUKEMIA AND NON-HODGKINS-LYMPHOMA NEAR LARGE RURAL CONSTRUCTION SITES, WITH A COMPARISON WITH SELLAFIELD NUCLEAR SITE
CHILDHOOD LEUKEMIA AND NON-HODGKINS-LYMPHOMA NEAR LARGE RURAL CONSTRUCTION SITES, WITH A COMPARISON WITH SELLAFIELD NUCLEAR SITE
复制标题
DOI：
10.1136/bmj.310.6982.763
复制
发表时间：
1995-03-25
影响因子：
105.7
通讯作者：
STILLER, CA
中科院分区：
文献类型：
--
作者：
KINLEN, LJ;DICKSON, M;STILLER, CA
目的：确定农村地区大型非核建设项目产生的人口混合是否与儿童白血病和非霍奇金淋巴瘤的增加有关。设计-研究1945年以来居住在英国大型建筑项目附近的儿童白血病和非霍奇金淋巴瘤的发病率，这些项目位于距离人口中心20多公里的地方，涉及1000多名劳动力，并且在三年或更长时间内建成。对1962年之前的死亡率进行了研究。设置-相关地点10公里范围内的区域，以及苏格兰高地县的许多水电项目。研究对象：15岁以下儿童。结果：0-14岁的白血病和非霍奇金淋巴瘤在建造期间和接下来的日历年增加了37%。在建筑工人和操作人员重叠的情况下（72%），尤其是在社会阶层相对较高的地区，这种情况更为严重。有几个地方的过剩量与塞拉菲尔德核电站附近的相似或更大（67%），塞拉菲尔德核电站的特点是劳动力众多，有许多建筑工人。Sellafield附近的Seascale，增长了9倍，其社会阶层i的居民比例异常高。唯一一个具有可比社会阶层的研究教区也显示出显著的过剩，其置信区间包括Seascale过剩。结论：这些发现支持了感染假说，并强化了塞拉菲尔德附近儿童白血病和非霍奇金淋巴瘤的过量存在类似解释的观点。
Objective-To determine whether population mixing produced by large, non-nuclear construction projects in rural areas is associated with an increase in childhood leukaemia and non-Hoodgkin's lymhoma.Design-A study of the incidence of leukaemia and non-Hodgkin's lymphoma among children living near large construction projects in Britain since 1945, situated more than 20 km from a population centre, involving a workforce of more than 1000, and built over three or more calendar years. For periods before 1962 mortality was studied.Setting-Areas within 10 km of relevant sites, and the highland counties of Scotland with many hydroelectric schemes.Subjects-Children aged under 15.Results-A 37% excess of leukaemia and non-Hodgkin's lymphoma at 0-14 years of age was recorded during construction and the following calendar year. The excesses were greater at times when construction workers and operating staff overlapped (72%), particularly in areas of relatively high social class. For several sites the excesses were similar to or greater than that near the nuclear site of Sellafield (67%), which is distinctive in its large workforce with many construction workers. Seascale, near Sellafield, with a ninefold increase had an unusually high proportion of residents in social class I. The only study parish of comparable social class also showed a significant excess, with a confidence interval that included the Seascale excess.Conclusion-The findings support the infection hypothesis and reinforce the view that the excess of childhood leukaemia and non-Hodgkin's lymphoma near Sellafield has a similar explanation.