Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.
Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.
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在印度尼西亚巴布亚，接触疟疾的爪哇移民中，减少传播的抗体迅速出现。
DOI：
10.4269/ajtmh.2006.74.425
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. Baird
中科院分区：
文献类型：
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作者：
J. T. Bousema;M. Bangs;J. Maguire;M. van de Vegte;W. Roeffen;R. Sauerwein;L. Kurniawan;S. D. de Vlas;K. Teelen;M. van der Kolk;J. Baird
恶性疟原虫疟疾的传播是由蚊子的性阶段开始的。与寄生虫一起摄入的抗 Pfs48/45 和抗 Pfs230 性阶段抗体可以减少寄生虫的发育和随后的疟疾传播。研究人员对 102 名无免疫力的爪哇人移民到流行病肆虐的巴布亚印度尼西亚的爪哇人进行了研究，研究了性阶段免疫力的获得情况。在抵达时以及第 6、12 和 24 个月时测量了抗 Pfs48/45 和 Pfs230 抗体的血清阳性率以及功能性传播减少活性 (TRA)。每两周评估一次无性寄生虫血症和配子体血症。 TRA 和血清反应性随着恶性疟原虫感染数量的增加而增加。 TRA 与 Pfs48/45（比值比 [OR] = 3.74，95% 置信区间 [CI] = 1.51-9.29）和 Pfs230（OR = 3.72，95% CI = 1.36-10.17）抗体之间的纵向持续关联表明，在有限的感染暴露后，获得了降低免疫力的功能性传递。
Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51-9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36-10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.