Epoxides--is there a human health problem?
Epoxides--is there a human health problem?
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环氧化物——对人类健康有影响吗？
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
M. Manson
中科院分区：
文献类型：
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作者：
M. Manson
本综述的目的是考虑环氧化物是否对人类健康构成危害。职业和非职业接触的可能手段进行了讨论，参考工业上重要的化合物和其他环氧化物，如天然植物和真菌产品的生产和使用。除了环氧化物本身之外，还包括可能在体内代谢为环氧化物的不饱和化合物，因为这似乎是另一种重要的接触方式。毒理学，特别是致癌性和致突变性，进行了讨论，沿着的生物化学，如代谢，结合细胞成分，和DNA修复机制的简要概述。不同的环氧化物在体内之间的相互作用的问题也被提出。
The purpose of this review is to consider whether epoxides represent a hazard to human health. Possible means of occupational and non-occupational exposure are discussed with reference to the production and uses of industrially important compounds and other epoxides, such as naturally occurring plant and fungal products. In addition to epoxides themselves, unsaturated compounds that may be metabolised in vivo to epoxides are included, since this appears to be a further important means of exposure. The toxicology, in particular carcinogenicity and mutagenicity, is discussed, along with a brief outline of the biochemistry such as metabolism, binding to cell constituents, and DNA repair mechanisms. The question of interactions between different epoxides in vivo is also raised.