Clonal Selection and Evolution of HTLV-1-Infected Cells Driven by Genetic and Epigenetic Alteration.
Clonal Selection and Evolution of HTLV-1-Infected Cells Driven by Genetic and Epigenetic Alteration.
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DOI：
10.3390/v14030587
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发表时间：
2022-03-12
期刊：
影响因子：
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通讯作者：
Uchimaru K
中科院分区：
文献类型：
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作者：
Yamagishi M;Suzuki Y;Watanabe T;Uchimaru K
感染人类T细胞白血病病毒1型（HTLV-1）的T细胞在长潜伏期内获得各种异常，并转化为高度恶性的成人T细胞白血病-淋巴瘤（ATL）细胞。这可以被描述为“克隆进化”，其中单个克隆在克服感染个体体内的各种选择压力后进化成ATL细胞。许多研究表明，基因组和表观基因组包含多种异常，这些异常反映在基因表达模式中，并定义了疾病的特征。最新的研究结果表明，表观基因组疾病被认为在感染早期开始形成，并通过进一步的变化和加重演变为ATL。基因组异常深刻地影响克隆优势和肿瘤细胞的特征，在以后的事件。ATL具有基因组和表观基因组异常，并且可以期望对这些异常的准确理解提供治疗机会。
T cells infected with human T-cell leukemia virus type 1 (HTLV-1) acquire various abnormalities during a long latent period and transform into highly malignant adult T-cell leukemia-lymphoma (ATL) cells. This can be described as “clonal evolution”, in which a single clone evolves into ATL cells after overcoming various selective pressures in the body of the infected individuals. Many studies have shown that the genome and epigenome contain a variety of abnormalities, which are reflected in gene expression patterns and define the characteristics of the disease. The latest research findings suggest that epigenomic disorders are thought to begin forming early in infection and evolve into ATL through further changes and accentuation as they progress. Genomic abnormalities profoundly affect clonal dominance and tumor cell characteristics in later events. ATL harbors both genomic and epigenomic abnormalities, and an accurate understanding of these can be expected to provide therapeutic opportunities.