Cortical stimulation induces fos expression in striatal neurons.
Cortical stimulation induces fos expression in striatal neurons.
复制标题
皮质刺激诱导纹状体神经元中 fos 的表达。
DOI：
10.1016/0306-4522(92)90055-7
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
Beckstead,RM
中科院分区：
文献类型：
--
作者：
Fu,L;Beckstead,RM
电刺激大鼠脑额顶叶皮质的广泛区域诱导纹状体神经元中通常缺乏蛋白质的免疫细胞化学可检测到Fos。纹状体神经元内的标记在15分钟长的刺激期停止后0.5小时达到最大值，并在3小时时变得较弱。尽管Fos反应神经元以不均匀的方式广泛分布在两个半球的纹状体中，但受刺激侧的神经元数量更多，染色更深。在苍白球、脚内核和黑质中均未发现标记神经元。6-羟基多巴胺的黑质纹状体多巴胺投射的破坏并没有诱导Fos的产生，并未能阻止皮质刺激诱导Fos。荧光金逆行标记证实了许多Fos阳性神经元投射到黑质，提示皮质纹状体兴奋性传递可能通过Fos直接影响纹状体神经元的基因组活动。
Electrical stimulation of a broad area of the frontoparietal cortex in the rat brain induces immunocytochemically detectable Fos in striatal neurons normally devoid of the protein. The vividness of labeling within striatal neurons was maximal at 0.5 h after the cessation of a 15-min-long stimulation period and became weaker by 3 h. Although Fos-reactive neurons were widely distributed in the striata of both hemispheres in an uneven pattern, those on the stimulated side were more numerous and more darkly stained. At no time-point were labeled neurons found in the globus pallidus, entopeduncular nucleus or substantia nigra. Destruction of the nigrostriatal dopamine projection with 6-hydroxydopamine did not induce Fos production and failed to prevent the induction of Fos by cortical stimulation. That many of the Fos-positive neurons project to the substantia nigra was confirmed by retrograde labeling with Fluoro-Gold.The data suggest that corticostriatal excitatory transmission may directly influence the genomic activity of striatal neurons by way of Fos.