Persistent neural activity in head direction cells
Persistent neural activity in head direction cells
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DOI：
10.1093/cercor/bhg102
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发表时间：
2003-11-01
期刊：
影响因子：
3.7
通讯作者：
Bassett, JP
中科院分区：
文献类型：
--
作者：
Taube, JS;Bassett, JP
大鼠边缘系统中的许多神经元放电与动物相对于其环境的方向性航向有关。这些所谓的头部方向（HD）细胞表现出持续神经活动的特征。本文总结了HD细胞的发现，它们的主要特性，以及一些重要的实验，已经进行了阐明如何产生这种信号。HD和头部角速度细胞的数量估计的几个脑区参与的HD信号的产生，包括后下托，前背丘脑，外侧乳头体核和背侧被盖核。HD细胞信号与已知的关于神经整合如何在眼神经系统中完成的特征有许多共同之处。HD细胞信号的性质使其成为使用神经网络模型来阐明信号的潜在机制的有吸引力的候选者。强调了任何网络模型必须满足的条件，以便准确地表示神经系统如何生成此信号，并讨论了关键信息缺失的区域。
Many neurons throughout the rat limbic system discharge in relation to the animal's directional heading with respect to its environment. These so-called head direction (HD) cells exhibit characteristics of persistent neural activity. This article summarizes where HD cells are found, their major properties, and some of the important experiments that have been conducted to elucidate how this signal is generated. The number of HD and angular head velocity cells was estimated for several brain areas involved in the generation of the HD signal, including the postsubiculum, anterior dorsal thalamus, lateral mammillary nuclei and dorsal tegmental nucleus. The HD cell signal has many features in common with what is known about how neural integration is accomplished in the oculomotor system. The nature of the HD cell signal makes it an attractive candidate for using neural network models to elucidate the signal's underlying mechanisms. The conditions that any network model must satisfy in order to accurately represent how the nervous system generates this signal are highlighted and areas where key information is missing are discussed.