Perfluoroalkyl substances in human milk: A first survey in Italy
Perfluoroalkyl substances in human milk: A first survey in Italy
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DOI：
10.1016/j.envint.2012.10.001
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发表时间：
2013-01-01
影响因子：
11.8
通讯作者：
Pagliuca, Giampiero
中科院分区：
文献类型：
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作者：
Barbarossa, Andrea;Masetti, Riccardo;Pagliuca, Giampiero
全氟烷基物质（PFAS）由于其广泛的扩散性，经常在环境和几种动物中发现。已经证明，它们也可以很容易地感染人类，主要是通过饮食。由于哺乳是消除这些污染物的主要途径，它们在人乳中的出现特别令人感兴趣，特别是考虑到它通常代表新生儿的独特食物来源。全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）是该家族中最重要的两种化合物，在母乳中经常发现浓度不等的全氟辛烷磺酸和全氟辛酸，但现有数据仍然有限。本研究首次在意大利进行，能够通过UPLC-MS/MS检测超痕量水平的这些污染物，证实了哺乳作为母乳喂养儿童接触源的作用。测得的全氟辛烷磺酸浓度在15至288纳克/升之间，全氟辛酸在24至241纳克/升之间。此外，两种分析物的平均浓度和频率导致产妇提供的乳汁样本更高，表明首次分娩的摄入风险可能更高。最后，将这些结果与以前的数据进行比较，证实了自2000年以来全氟辛烷磺酸逐渐减少。(c)2012爱思唯尔有限公司保留所有权利。
Due to their widespread diffusion, perfluoroalkyl substances (PFASs) have been frequently found in the environment and in several animal species. It has been demonstrated that they can easily reach also humans, mainly through diet. Being lactation a major route of elimination of these contaminants, their occurrence in human milk is of particular interest, especially considering that it generally represents the unique food source for newborns. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), the two most important compounds of this family, have been frequently found in human milk at variable concentrations, but still limited data are available. The present study, the first conducted in Italy capable to detect these pollutants at ultra-trace levels by UPLC-MS/MS, confirmed the role of lactation as a relevant source of exposure for breastfed children. The measured concentrations ranged between 15 and 288 ng/L for PFOS and between 24 and 241 ng/L for PFOA. Moreover, mean concentrations and frequencies of both analytes resulted higher in milk samples provided by primiparous women, suggesting that the risk of intake might be higher for first-borns. Finally, comparing these results with previous data, PFOS gradual decrease over time since year 2000 was confirmed. (c) 2012 Elsevier Ltd. All rights reserved.