Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets (Callithrix jacchus)
Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets (Callithrix jacchus)
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DOI：
10.1111/j.1600-0684.2007.00220.x
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发表时间：
2007-12-01
影响因子：
0.7
通讯作者：
Kai, C.
中科院分区：
文献类型：
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作者：
Kodama, A.;Yanai, T.;Kai, C.
背景马疱疹病毒9 （EHV-9）是一种新的嗜神经马疱疹病毒，可在多种动物中引起脑炎。然而，没有关于灵长类动物对EHV-9易感性的信息。方法采用鼻路接种4只普通狨猴，接种10(6)个EHV-9菌斑单位。结果与结论所有接种动物均表现出不同程度的神经学症状，并逐渐发展到崩溃。组织学上表现为严重的脑炎，以神经元变性坏死为特征，核内包涵体从嗅球延伸到鼻脑和梨状叶。免疫组化在退行性神经细胞中发现EHV-9抗原。鼻腔内有严重的坏死性鼻炎，嗅觉粘膜内有明显的核内包涵体。这些发现表明狨猴对EHV-9易感。
Background Equine herpesvirus 9 (EHV-9) is a new neurotropic equine herpesvirus which induced encephalitis in a variety of animals. However, there was no information on the susceptibility of EHV-9 in primates.Methods To assess the infectivity of EHV-9, four common marmosets (Callithrix jacchus) were inoculated by the nasal route with 10(6) plaque-forming units of EHV-9.Results and conclusions All of the inoculated animals exhibited various neurological signs progressing to collapse. Histologically, the affected animals had severe encephalitis characterized by neuronal degeneration and necrosis with intranuclear inclusion bodies, which extended from the olfactory bulb to the rhinencephalon and piriform lobe. Immunohistochemistry revealed EHV-9 antigens in degenerating neuronal cells. The nasal cavity had severe necrotizing rhinitis with prominent intra-nuclear inclusion bodies in the olfactory mucosa. These findings indicate that the marmosets are susceptible to EHV-9.