Auditory brainstem responses predict auditory nerve fiber thresholds and frequency selectivity in hearing impaired chinchillas.
Auditory brainstem responses predict auditory nerve fiber thresholds and frequency selectivity in hearing impaired chinchillas.
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DOI：
10.1016/j.heares.2011.06.002
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发表时间：
2011-10
期刊：
影响因子：
2.8
通讯作者：
Heinz, Michael G.
中科院分区：
文献类型：
--
作者：
Henry, Kenneth S.;Kale, Sushrut;Scheidt, Ryan E.;Heinz, Michael G.
在临床和研究环境中，非侵入性听性脑干反应(ABR)通常用于评估耳蜗病理学。在目前的研究中，我们评估了ABR特征与更直接的耳蜗功能测量之间的关系。我们记录了7只噪声性听力损失的栗鼠的ABR和听神经(AN)单位反应。在暴露于中心频率为2 kHz的115dBSPL、50 HZ频段的噪声的4小时前和数周后，记录1-8 KHZ短纯音刺激的ABR。在相同的动物中，将听力损失后ABR特性(阈值、I波幅度和I波潜伏期)的变化与AN纤维调谐曲线特性(阈值和频率选择性)进行比较。正如预期的那样，噪声暴露通常会导致ABR阈值的增加和相同SPL时I波幅度的降低。然而，在相同感觉水平(SL)下，噪声暴露前后的I波幅度相似。此外，噪声暴露导致相同SL和相同SPL时ABR波I潜伏期的减少，程度较小。ABR特征的变化与同一动物在相同频率下的AN纤维调谐曲线特性显著相关。ABR阈值和相同SPL时ABR波I波幅的较大移位与较大的阈值升高相关。另一方面，在相同SL时，ABR波I潜伏期的较大缩短与频率选择性的更大损失有关。这一结果与线性系统理论相一致，线性系统理论预测了更广泛的外围频率调谐的较短时间延迟。结合其他研究，我们的结果肯定了ABR阈值和波I波幅提供了对耳蜗敏感度的有用估计。此外，ABR波I潜伏期与相同SL下的正常数据的比较可能被证明对于检测和表征耳蜗频率选择性的丧失是有用的。
Non-invasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit responses in seven chinchillas with noise induced hearing loss. ABRs were recorded for 1–8 kHz tone burst stimuli both before and several weeks after four hours of exposure to a 115 dB SPL, 50 Hz band of noise with a center frequency of 2 kHz. Shifts in ABR characteristics (threshold, wave I amplitude, and wave I latency) following hearing loss were compared to AN-fiber tuning curve properties (threshold and frequency selectivity) in the same animals. As expected, noise exposure generally resulted in an increase in ABR threshold and decrease in wave I amplitude at equal SPL. Wave I amplitude at equal sensation level (SL), however, was similar before and after noise exposure. In addition, noise exposure resulted in decreases in ABR wave I latency at equal SL and, to a lesser extent, at equal SPL. The shifts in ABR characteristics were significantly related to AN-fiber tuning curve properties in the same animal at the same frequency. Larger shifts in ABR thresholds and ABR wave I amplitude at equal SPL were associated with greater AN threshold elevation. Larger reductions in ABR wave I latency at equal SL, on the other hand, were associated with greater loss of AN frequency selectivity. This result is consistent with linear systems theory, which predicts shorter time delays for broader peripheral frequency tuning. Taken together with other studies, our results affirm that ABR thresholds and wave I amplitude provide useful estimates of cochlear sensitivity. Furthermore, comparisons of ABR wave I latency to normative data at the same SL may prove useful for detecting and characterizing loss of cochlear frequency selectivity.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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