Low-level cadmium exposure and osteoporosis
Low-level cadmium exposure and osteoporosis
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DOI：
10.1359/jbmr.2000.15.8.1579
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发表时间：
2000-08-01
影响因子：
6.2
通讯作者：
Järup, L
中科院分区：
文献类型：
--
作者：
Alfvén, T;Elinder, CG;Järup, L
骨质疏松症是全世界发病的主要原因。许多风险因素，例如年龄和性别，都是明确的。高镉暴露会导致肾损伤，严重时还会导致骨质疏松和骨软化。我们研究了长期高浓度镉暴露是否会增加骨质疏松的风险。使用双能 X 射线吸收测定法 (DXA) 技术测量了 520 名男性和 544 名女性的前臂骨矿物质密度 (BMD)，这些男性年龄在 16 至 81 岁，环境或职业接触镉。尿液中的镉被用作剂量估计，蛋白质 HC 被用作肾小管损伤的标志物。镉剂量与肾小管性蛋白尿患病率之间存在明显的剂量反应关系。镉剂量、肾小管蛋白尿和骨密度之间存在负相关关系，特别是在60岁以上的人群中尤为明显，镉剂量与骨质疏松之间存在剂量反应关系。与最低剂量组相比，0.5-3 nmol Cd/mmol 肌酐剂量组中男性的比值比 (OR) 为 2.2 (95% CI，1.0-4.8)，最高剂量类别（大于或等于 3 nmol/mmol 肌酐）的比值比 (OR) 为 5.3 (2.0-14)。
Osteoporosis is a major cause of morbidity worldwide. A number of risk factors, such as age and gender, are well established. High cadmium exposure causes renal damage and in severe cases also causes osteoporosis and osteomalacia, We have examined whether long-term Pow-level cadmium exposure increases the risk of osteoporosis. Bone mineral density (BMD) in the forearm was measured in 520 men and 544 women, aged 16-81 years, environmentally or occupationally exposed to cadmium, using dual-energy X-ray absorptiometry (DXA) technique. Cadmium in urine was used as the dose estimate and protein HC was used: as a marker of renal tubular damage. There was a clear dose-response relation between cadmium dose and the prevalence of tubular proteinuria. Inverse relations were found between cadmium dose, tubular proteinuria, and BMD, particularly apparent in persons over 60 years of age, There was a dose-response relation between cadmium dose and osteoporosis. The odds ratios (ORs) for men were 2.2 (95% CI, 1.0-4.8) in the dose group 0.5-3 nmol Cd/mmol creatinine and 5.3 (2.0-14) in the highest dose category (greater than or equal to 3 nmol/mmol creatinine) compared with the lowest dose group (