A high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens.
A high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens.
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DOI：
10.3390/brainsci2020242
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发表时间：
2012-06-11
期刊：
影响因子：
3.3
通讯作者：
Leibowitz SF
中科院分区：
文献类型：
--
作者：
Rada P;Avena NM;Barson JR;Hoebel BG;Leibowitz SF
有证据表明，多巴胺（DA）在神经核（NAc）壳的摄入可口的饮食。然而，关于DA与膳食脂肪和循环甘油三酯（TG）的具体关系知之甚少，这些脂肪被脂肪摄入刺激并促进暴饮暴食。目前的实验测试在Sprague-Dawley大鼠细胞外水平的NAc DA是否增加响应于急性访问到富含脂肪的食物或外周注射的脂肪乳剂，如果是这样，这是否与热量摄入或循环脂质升高。当大鼠消耗更多的热量的高脂肪餐相比，低脂肪餐，有一个显着增加细胞外多巴胺（155%对119%）。全身注射脂肪乳剂，这就像一个高脂肪饮食提高循环TG，但消除了味道的因素，并允许控制热量摄入，也显着增加细胞外DA水平（127%）相比，equicaloric葡萄糖溶液（70%）和盐水（85%）。总之，这表明循环TG的升高可能有助于高脂肪饮食对NAc DA的刺激作用。
Evidence links dopamine (DA) in the nucleus accumbens (NAc) shell to the ingestion of palatable diets. Less is known, however, about the specific relation of DA to dietary fat and circulating triglycerides (TG), which are stimulated by fat intake and promote overeating. The present experiments tested in Sprague-Dawley rats whether extracellular levels of NAc DA increase in response to acute access to fat-rich food or peripheral injection of a fat emulsion and, if so, whether this is related to caloric intake or elevated circulating lipids. When rats consumed more calories of a high-fat meal compared with a low-fat meal, there was a significant increase in extracellular accumbens DA (155% vs. 119%). Systemic injection of a fat emulsion, which like a high-fat diet raises circulating TG but eliminates the factor of taste and allows for the control of caloric intake, also significantly increased extracellular levels of DA (127%) compared to an equicaloric glucose solution (70%) and saline (85%). Together, this suggests that a rise in circulating TG may contribute to the stimulatory effect of a high-fat diet on NAc DA.