Ancestry and Risk of Hepatic Fibrosis and Inflammation in Patients With HCV Infection.

Ancestry and Risk of Hepatic Fibrosis and Inflammation in Patients With HCV Infection.
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HCV 感染患者的血统以及肝纤维化和炎症的风险。

DOI：
10.1016/j.cgh.2018.10.024
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发表时间：
2019
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
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通讯作者：
El-Serag,HashemB
El-Serag,HashemB
中科院分区：
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文献类型：
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作者：
Thrift,AaronP;Liu,Yanhong;Tsavachidis,Spiridon;White,DonnaL;El-Serag,HashemB

文献摘要

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这是一项在NHW，黑人和西班牙裔男性慢性HCV感染患者中进行的横断面研究，这些患者来自一家退伍军人事务部（VA）医院。5名参与者完成了研究调查，进行了抽血和FibroSURE，并进行了人体测量。FibroSURE确定的纤维化分期F3/F4-F4的患者定义为晚期纤维化病例。具有F0-F3的那些被定义为轻度纤维化对照。我们将炎症分级为A2/A3-A3的患者定义为晚期炎症活动病例，将炎症分级为A0-A2的患者定义为轻度活动对照。
MethodsThis was a cross-sectional study among NHW, black, and Hispanic male patients with chronic HCV infection from a single Veterans Affairs (VA) hospital. 5 Participants completed a study survey, underwent a blood draw and FibroSURE, and had anthropometric measurements taken. Patients with FibroSURE-determined fibrosis stage F3/F4–F4 were defined as advanced fibrosis cases. Those with F0–F3 were defined as mild fibrosis controls. We defined as advanced inflammatory activity cases those patients with inflammatory grades A2/A3–A3, and mild activity controls as those patients with inflammatory grades A0–A2.