Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes - The ARIC study
Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes - The ARIC study
复制标题
DOI：
10.1161/01.cir.102.11.1239
复制
发表时间：
2000-09-12
期刊：
影响因子：
37.8
通讯作者：
Schouten, EG
中科院分区：
文献类型：
--
作者：
Dekker, JM;Crow, RS;Schouten, EG
背景--低心率变异性(HRV)与心脏病患者和老年受试者的高死亡风险以及普通人群中较高的冠心病(CHD)发病率相关。方法和结果：我们采用病例队列设计，在14672名年龄在45-65岁的非冠心病男性和女性的人群研究中，研究了HRV对冠心病和多种原因死亡的预测价值。在1987年至1989年的基线上，记录了2分钟的节律带。心率变异的时间域测量是在900名随机抽样的受试者中确定的，包括所有发生冠心病的受试者(395名受试者)和1993年发生的所有死亡(443名受试者)。病例队列设计采用Poisson回归方法，计算冠心病发病率和HRV的死因相关死亡率。心率变异性低的受试者有不良的心血管风险，发生冠心病和死亡的风险增加。死亡风险的增加不能归因于特定的原因，也不能用其他危险因素来解释，结论-低HRV与CHD和多种原因死亡的风险增加相关，假设低HRV是健康状况不佳的标志。
Background-Low heart rate variability (HRV) is associated with a higher risk of death in patients with heart disease and in elderly subjects and with a higher incidence of coronary heart disease (CHD) in the general population.Methods and Results-We studied the predictive value of HRV for CHD and death from several causes in a population study of 14 672 men and women without CHD, aged 45 to 65, by using the case-cohort design. At baseline, in 1987 to 1989, 2-minute rhythm strips were recorded. Time-domain measures of HRV were determined in a random sample of 900 subjects, for all subjects with incident CHD (395 subjects), and for all deaths (443 subjects) that occurred through 1993. Relative rates of incident CHD and cause-specific death in tertiles of HRV were computed with Poisson regression for the case-cohort design. Subjects with low HRV had an adverse cardiovascular risk profile and an elevated risk of incident CHD and death. The increased risk of death could not be attributed to a specific cause and could not be explained by other risk factors,Conclusions-Low HRV was associated with increased risk of CHD and death from several causes, It is hypothesized that low HRV is a marker of less favorable health.