Methionine and vitamin B6 intake and risk of pancreatic cancer:: A prospective study of Swedish women and men
Methionine and vitamin B6 intake and risk of pancreatic cancer:: A prospective study of Swedish women and men
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DOI：
10.1053/j.gastro.2006.10.017
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发表时间：
2007-01-01
期刊：
影响因子：
29.4
通讯作者：
Wolk, Alicja
中科院分区：
文献类型：
--
作者：
Larsson, Susanna G.;Giovannucci, Edward;Wolk, Alicja
背景与目的：甲硫氨酸、叶酸和维生素B-6等参与甲基代谢的饮食因素可能会改变癌症的风险。我们之前曾报道过，在一组瑞典女性和男性的前瞻性人群队列中，叶酸摄入量与胰腺癌风险之间存在负相关。在目前的研究中，我们使用这项前瞻性研究的数据来检验蛋氨酸和维生素B6的摄入量是否与胰腺外分泌癌的发病率有关。方法：我们的研究人群包括81,922名年龄在45-83岁的瑞典女性和男性，他们没有患癌症，并于1997年完成了自我管理的食物频率问卷。我们使用COX比例风险模型，根据年龄、性别、教育程度、吸烟、体重指数、糖尿病、总能量和饮食叶酸的摄入量进行调整后，以95%的可信区间(CI)估计危险比。结果：在平均7.2年的随访中，截至2005年6月，147例胰腺癌病例被诊断。蛋氨酸摄入量与胰腺癌风险呈显著负相关，而饮食或总维生素B6摄入量则没有明显相关性。比较蛋氨酸摄入量最高和最低四分位数的多变量比率在男女组合中为0.44(95%CI，0.26-0.73；趋势=0.0005)，女性为0.59(95%CI，0.28-1.21；趋势=0.07)，男性为0.32(95%CI，0.15-0.65；趋势=0.002)。结论：这些发现表明，较高的蛋氨酸摄入量可能会降低胰腺癌的风险。
Background & Aims: It has been hypothesized that dietary factors involved in methyl group metabolism, such as methionine, folate, and vitamin B-6, may modify cancer risk. We have previously reported an inverse association between folate intake and pancreatic cancer risk in a prospective population-based cohort of Swedish women and men. In the present study, we used data from this prospective study to examine whether methionine and vitamin B6 intakes were associated with the incidence of exocrine pancreatic cancer. Methods: Our study population comprised 81,922 Swedish women and men, aged 45-83 years, who were free from cancer and completed a self-administered food-frequency questionnaire in 1997. We used Cox proportional hazards models to estimate rate ratios with 95% confidence intervals (CI), adjusted for age, sex, education, smoking, body mass index, diabetes, and intakes of total energy and dietary folate. Results: During a mean follow-up of 7.2 years, through June 2005, 147 incident cases of pancreatic cancer were diagnosed. Methionine intake was significantly inversely associated with risk of pancreatic cancer, whereas no significant association was observed for dietary or total vitamin B6 intake. The multivariate rate ratios comparing the highest with the lowest quartile of methionine intake were 0.44 (95% CI, 0.26-0.73; P for trend = .0005) in women and men combined, 0.59 (95% CI, 0.28-1.21; P for trend = .07) in women, and 0.32 (95% CI, 0.15-0.65; P for trend = .002) in men. Conclusions: These findings suggest that higher methionine intake may reduce the risk of pancreatic cancer.