Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
复制标题
神经周围侵袭与 p38 丝裂原激活蛋白激酶通路激活有关，并促进胰腺癌的肿瘤生长和化疗耐药
DOI：
10.1002/jcb.28457
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发表时间：
2019
影响因子：
4
通讯作者：
Chen Hao
中科院分区：
文献类型：
--
作者：
Gu Jiangning;Xu Wei;Peng Chenghong;Zhu Youwei;Wang Di;Wang Xuelong;Li Ying;Wei Gang;Zhang Zhiqiang;Zhong Yiming;Zhao Shulin;Shi Minmin;Cheng Dongfeng;Ying Xiayang;Jin Jiabin;Chen Hao
Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is unclear. This study was conducted to identify the key components and signaling pathways involved in the perineural invasion of pancreatic cancer and alterations in the phenotype after the interaction between the dorsal root ganglion (DRG) and pancreatic cancer cells. The results indicated that the p38 mitogen‐activated protein kinase signaling pathway was activated after coculture of the DRG and pancreatic cancer cells and lead to the promotion of cell growth and chemoresistance.
