Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors.
Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors.
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DOI：
10.1016/j.coph.2020.08.006
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发表时间：
2020-10
影响因子：
4
通讯作者：
Hazlehurst LA
中科院分区：
文献类型：
--
作者：
Chen WC;Hu G;Hazlehurst LA
The bone marrow microenvironment (BMM) provides input via production of cytokines, chemokines, extracellular matrixes in the context of lower oxygen levels that influences self-renewal, survival, differentiation, progression and therapeutic resistance of multiple myeloma and leukemic cells. Within the context of the BMM, tumor cells are supported by osteoblasts, bone marrow stromal cells (BMSCs), fibroblasts, myeloid cells, endothelial cells and blood vessels as well as extracellular matrix (ECM) that contribute to tumor progression. Environmental mediated-drug resistance (EM-DR) contains cell adhesion mediated drug resistance (CAM-DR) and soluble factor mediated drug resistance (SM-DR) that contributes to de-novo drug resistance. In this review, we focus on the crosstalk between the BMM and tumor cells as well as mechanisms underlying the BMM contributing to drug resistance in hematologic malignancies.
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影响因子：
20.3
作者：
Cho, Byung-Sik;Zeng, Zhihong;Konopleva, Marina
通讯作者：
Konopleva, Marina
DOI：
10.2967/jnumed.114.144881
发表时间：
2014-11
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Beaino W;Anderson CJ
通讯作者：
Anderson CJ
影响因子：
20.3
作者：
Damiano, JS;Cress, AE;Dalton, WS
通讯作者：
Dalton, WS
影响因子：
11.4
作者：
Cheung, WC;Van Ness, B
通讯作者：
Van Ness, B
影响因子：
11.4
作者：
Damiano, JS;Hazlehurst, LA;Dalton, WS
通讯作者：
Dalton, WS