CORTICALLY PROJECTING CELLS IN THE PERIAQUEDUCTAL GRAY-MATTER OF THE RAT - A RETROGRADE FLUORESCENT TRACER STUDY
CORTICALLY PROJECTING CELLS IN THE PERIAQUEDUCTAL GRAY-MATTER OF THE RAT - A RETROGRADE FLUORESCENT TRACER STUDY
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DOI：
10.1016/0006-8993(91)90029-u
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发表时间：
1991-03-15
期刊：
影响因子：
2.9
通讯作者：
GONZALO, LM
中科院分区：
文献类型：
--
作者：
HERRERO, MT;INSAUSTI, R;GONZALO, LM
用荧光示踪剂固蓝（FB）和二脒基黄（DY）逆行追踪大鼠中脑导水管周围灰质（PAG）向大脑皮质的传入纤维，研究了PAG向大脑皮质传入纤维的地形结构。通过将两种荧光示踪剂放入两个不同的皮质区域，探索了嗅觉、内侧额叶（边缘下、边缘前和前扣带皮质）、外侧额叶（运动）、顶叶、颞叶、枕叶和岛叶皮质。PAG中内侧额叶皮质注射的标记神经元数量最多，其次是嗅觉和外侧额叶皮质。注射后，顶叶、颞枕叶和岛叶皮质的逆行标记细胞减少。所有标记的细胞都只位于PAG的内侧和外侧腹侧部（PAGM和PAGlv）。PAGM中标记的纵向范围比PAGlv中更广泛。内侧额叶皮质组的标记神经元延伸到PAG的大部分，而在其余组中，标记神经元仅限于PAG的尾侧1/3。投射到两个不同皮层区域的神经元只是标记细胞总数的一小部分。我们的数据表明，内侧额叶皮层是直接PAG输入的最重要的受体，其次是外侧额叶皮层。顶叶、颞叶、枕叶和岛叶皮质仅接受较小的投射。它的结论是PAG发送直接的预测在大多数的皮质地幔。因此，大脑皮层可能直接受到脑干的影响，而不经过丘脑。
The topographical organization of the afferent input from the periaqueductal gray matter (PAG) to the cerebral cortex has been assessed in rats by retrograde transport of the fluorescent tracers Fast blue (FB) and Diamidino yellow (DY). The olfactory, medial frontal (infralimbic, prelimbic and anterior cingulate cortices), lateral frontal (motor), parietal, temporal, occipital and insular cortices were explored by placing two fluorescent tracers into two different cortical regions. The PAG contained the largest number of labeled neurons in medial frontal cortex injections, followed by olfactory and lateral frontal cortices. Fewer retrogradely labeled cells were seen after injections in parietal, temporal occipital and insular cortices. All labeled cells were exclusively located in the medial and lateroventral divisions of the PAG (PAGm and PAGlv). The longitudinal extent of the labeling in PAGm was more extensive than in PAGlv. The labeled neurons in the medial frontal cortex group extended through most of the PAG, while in the remaining groups it was restricted to the caudal one-third of the PAG. Neurons with projections to two different cortical regions were only a small fraction of the total population of labeled cells. Our data indicate that the medial frontal cortex is the most important recipient of a direct PAG input, followed by the lateral frontal cortex. Parietal, temporal, occipital and insular cortices receive only a minor projection. It is concluded that the PAG sends direct projections over the majority of the cortical mantle. Therefore, the possibility arises that the cerebral cortex receives a direct influence from the brainstem without a thalamic relay.