Dose-response relationship for life-shortening and carcinogenesis in mice irradiated at day 7 postnatal age with dose range below 1 Gy of gamma rays
Dose-response relationship for life-shortening and carcinogenesis in mice irradiated at day 7 postnatal age with dose range below 1 Gy of gamma rays
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DOI：
10.1269/jrr.47.135
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发表时间：
2006-06-01
影响因子：
2
通讯作者：
Fukuda, Nobuo
中科院分区：
文献类型：
--
作者：
Sasaki, Shunsaku;Fukuda, Nobuo
本研究旨在阐明在婴儿时期给予低于1 Gy的伽马射线的剂量范围内缩短寿命和致瘤作用的剂量-反应关系。雌性B6C3F1小鼠在7日龄时分别接受0.10、0.48和0.95 Gy的辐射。所有受辐照的小鼠在特定的无病原体条件下与同时进行的对照组一起度过其整个生命周期。0.10 Gy辐照小鼠平均寿命缩短1.58%，差异有统计学意义。缩短寿命的线性剂量效应系数为11.21% Gy（-1）。0.10 Gy组所有死因的归因死亡率达到0.092。在接受0.10 Gy辐射的组中，所有原因导致的死亡率的相对风险为0.102。所有原因造成的死亡率的超相对危险度的线性剂量-反应关系系数为1.30 Gy（-1）。0.10 Gy辐照小鼠死亡时实体瘤的平均种类数明显大于对照组。在接受0.10 Gy辐射的小鼠中，实体瘤死亡率的超额相对风险为0.45。实体瘤死亡率的超相对危险度线性剂量-反应关系系数为4.52 Gy（-1）。0.10 Gy照射小鼠的垂体、卵巢和肾上腺肿瘤发生率增加。本研究结果表明，幼鼠易受实体瘤的诱导，尤其是内分泌器官。
This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out their entire life span together with a simultaneously ongoing control group under a specific pathogen-free condition. Shortening of the mean life span was 1.58% in mice irradiated with 0.10 Gy, which was statistically significant. The coefficient of the linear dose-response relationship for life-shortening was 11.21% Gy(-1). The attributable death fraction for all causes of death in 0.10 Gy froup reached 0.092. The excess relative risk for death rate from all causes was 0.102 in the group irradiated with 0.10 Gy. The coefficient of the linear dose-response relationship of the excess relative risk for death rate from all causes was 1.30 Gy(-1). The mean number of types of solid tumors at the time of death in mice irradiated with 0.10 Gy was distinctly larger than that in the control group. The excess relative risk for death rate from solid tumors was 0.45 in mice irradiated with 0.10 Gy. The coefficient of the linear dose-response relationship of excess relative risk for death rate from solid tumors was 4.52 Gy(-1). Increase in incidences of the pituitary, ovarian and adrenal tumors was observed in mice irradiated with 0.10 Gy. The results of the present study showed that infant mice are susceptible to solid tumor induction, especially of the endocrine organs.