Conditioning method dramatically alters the role of amygdala in taste aversion learning.
Conditioning method dramatically alters the role of amygdala in taste aversion learning.
复制标题
DOI：
10.1101/lm.5.6.481
复制
发表时间：
1998-11
影响因子：
2
通讯作者：
G. Schafe;Todd E. Thiele;Ilene L. Bernstein
中科院分区：
文献类型：
--
作者：
G. Schafe;Todd E. Thiele;Ilene L. Bernstein
虽然杏仁核在味觉厌恶学习中的重要作用已经被许多实验室的工作所暗示，但结果并不一致，解释也各不相同。目前的一系列研究重新评估杏仁核在味觉厌恶学习中的作用，通过检查条件反射方法，测试方法和损伤方法，影响杏仁核损伤是否显着影响条件性味觉厌恶（CTA）学习的程度。结果表明，当动物条件与口内（I/O）的味道介绍，杏仁核病变消除的证据，无论动物是测试口内或两瓶溶液介绍条件。杏仁核损伤对CTA学习的巨大影响，无论是电解损伤还是使用兴奋毒素。与此相反，当动物条件使用瓶介绍的味道，电解病变衰减CTA，但没有消除他们，和兴奋性毒性病变没有影响。这些结果是一致的假设，CTA学习的关键神经结构可能会有所不同，这取决于在何种程度上的条件刺激传递的方法纳入了响应组件。
Although an important role for the amygdala in taste aversion learning has been suggested by work in a number of laboratories, results have been inconsistent and interpretations varied. The present series of studies reevaluated the role of the amygdala in taste aversion learning by examining the extent to which conditioning methods, testing methods and lesioning methods, influence whether amygdala lesions dramatically affect conditioned taste aversion (CTA) learning. Results indicated that when animals are conditioned with an intraoral (I/O) taste presentation, lesions of amygdala eliminate evidence of conditioning whether animals are tested intraorally or with a two-bottle solution presentation. Dramatic effects of amygdala lesions on CTA learning were seen whether lesions were made electrolytically or using an excitotoxin. In contrast, when animals were conditioned using bottle presentation of the taste, electrolytic lesions attenuated CTAs but did not eliminate them, and excitotoxic lesions had no effect. These results are consistent with the hypothesis that neural structures critical for CTA learning may differ depending on the extent to which the method of conditioned stimulus delivery incorporates a response component.