Predicting Medication Adherence and Employment Status Following Kidney Transplant: The Relative Utility of Traditional and Everyday Cognitive Approaches
Predicting Medication Adherence and Employment Status Following Kidney Transplant: The Relative Utility of Traditional and Everyday Cognitive Approaches
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DOI：
10.1037/a0018670
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发表时间：
2010-07-01
期刊：
影响因子：
2.4
通讯作者：
Thornton, W. J. L.
中科院分区：
文献类型：
--
作者：
Gelb, Shannon R.;Shapiro, R. J.;Thornton, W. J. L.
目的：作者调查了传统和日常认知测量在预测肾移植受者的药物依从性和就业状况方面的效用。此外，非认知预测的作用进行了检查。方法：对108名肾移植受者进行了处理速度、记忆力、日常问题解决能力、执行功能和评估情绪、药物依从性和就业状况的问卷调查。由于两项分析的合格标准不同，药物依从性分析中有103名参与者，就业分析中有94名参与者。分别对连续和二分结局指标进行逐步分层回归和序贯二项logistic回归分析。结果如下：研究结果表明，在日常问题解决测试中表现较差和抑郁症状数量较多都预示着自我报告的药物依从性较差（R-2 = .19，p < .01）。此外，正在服用抗抑郁药物，有更多的抑郁症状，以及传统神经心理学指标的表现较差，预示着工作时间更少（Nagelkerke的R-2 = 0.29）。ps < .05）。结论：这项研究强调了肾移植后神经认知和心理社会状态与药物依从性和就业状况之间的差异。研究结果表明，传统和日常措施的相对重要性取决于检查的结果。
Objective: The authors investigated the utility of both traditional and everyday cognitive measures in predicting medication adherence and employment status among kidney transplant recipients. In addition, the role of noncognitive predictors was examined. Method: Cognitive measures of processing speed, memory, everyday problem solving, executive functioning, and questionnaires assessing mood, medication adherence, and employment status were individually administered to 108 kidney transplant recipients. Because the eligibility criteria differed for the two analyses, there were 103 participants in the medication adherence analyses and 94 participants in the employment analyses. Stepwise hierarchical regression and sequential binomial logistic regression analyses were conducted for continuous and dichotomous outcome measures, respectively. Results: Findings indicate that both poorer performance on the everyday problem-solving test and a higher number of depressive symptoms were predictive of poorer self-reported medication adherence (R-2 = .19, p < .01). Furthermore, being on antidepressant medication, having a higher number of depressive symptoms, and poorer performance on traditional neuropsychological measures were predictive of fewer hours worked (Nagelkerke's R-2 = .29. ps < .05). Conclusions: This study highlights the differential associations between neurocognitive and psychosocial status, and medication adherence and employment status following kidney transplantation. The findings suggest that the relative importance of traditional and everyday measures is dependent upon the outcome examined.