Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out.
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out.
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DOI：
10.1159/000493217
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Guo LW
中科院分区：
文献类型：
--
作者：
Zent J;Guo LW
Myofibroblasts are central mediators of fibrosis. Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally defined by acquired contractile function and high synthetic ability to produce extracellular matrix (ECM). Current literature sheds new light on the critical role of ECM signaling coupled with mechanotransduction in driving myofibroblastic activation. In particular, transforming growth factor β1 (TGF-β) and extra domain A containing fibronectin (EDA-FN) are thought to be the primary ECM signaling mediators that form and also induce positive feedback loops. The outsidein and inside-out signaling circuits are transmitted and integrated by TGF-β receptors and integrins at the cell membrane, ultimately perpetuating the abundance and activities of TGF-β and EDA-FN in the ECM. In this review, we highlight these conceptual advances in understanding myofibroblastic activation, in hope of revealing its therapeutic anti-fibrotic implications.
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影响因子：
7.3
作者：
Booth, Adam J.;Wood, Sherri C.;Cornett, Ashley M.;Dreffs, Alyssa A.;Lu, Guanyi;Muro, Andres F.;White, Eric S.;Bishop, D. Keith
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DOI：
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发表时间：
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期刊：
Nature reviews. Drug discovery
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