Membrane adhesion via competing receptor/ligand bonds
Membrane adhesion via competing receptor/ligand bonds
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DOI：
10.1209/epl/i2006-10317-0
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发表时间：
2006-11-01
期刊：
影响因子：
--
通讯作者：
Weikl, T. R.
中科院分区：
文献类型：
--
作者：
Asfaw, M.;Rozycki, B.;Weikl, T. R.
生物膜的粘附是由各种类型的受体和配体分子控制的。在这封信中，我们提出了通过两种不同长度的受体/配体键相互作用的膜的统计力学模型。我们表明膜的平衡相行为由有效双阱电势控制。两个势阱的深度取决于受体和配体的浓度和结合能。对于较小的膜，膜不受束缚，对于较大的潜在深度，膜受到束缚。在结合状态下，受体/配体键的长度不匹配会导致横向相分离。我们推导出解束缚和相分离临界点的显式标度定律，并通过与蒙特卡罗结果比较来确定先因子。
The adhesion of biological membranes is controlled by various types of receptor and ligand molecules. In this letter, we present a statistical-mechanical model for membranes that interact via receptor/ligand bonds of two different lengths. We show that the equilibrium phase behavior of the membranes is governed by an effective double-well potential. The depths of the two potential wells depend on the concentrations and binding energies of the receptors and ligands. The membranes are unbound for small, and bound for larger potential depths. In the bound state, the length mismatch of the receptor/ligand bonds can lead to lateral phase separation. We derive explicit scaling laws for the critical points of unbinding and phase separation, and determine the prefactors by comparison with Monte Carlo results.