A shift from diffuse to focal cortical activity with development
A shift from diffuse to focal cortical activity with development
复制标题
DOI：
10.1111/j.1467-7687.2005.00454.x
复制
发表时间：
2006-01-01
影响因子：
3.7
通讯作者：
Casey, BJ
中科院分区：
文献类型：
--
作者：
Durston, S;Davidson, MC;Casey, BJ
近期的影像学研究表明，随着时间的推移，皮质激活变得不那么弥散而更具局灶性，发育变化可能与成人学习的某些方面相似。然而，成人学习研究考察的是个体内部的变化，而发育方面的研究结果是基于横断面样本，甚至是跨研究的比较。在此，我们在一项纵向和横断面相结合的研究中，利用儿童的功能性磁共振成像，直接测试在执行一项认知控制任务期间皮质活动的变化。与横断面研究结果相比，我们的纵向研究结果显示，背外侧前额叶皮质区域的激活减弱，与此同时，与任务表现相关的腹侧前额叶区域的局灶性激活增强。
Recent imaging studies have suggested that developmental changes may parallel aspects of adult learning in cortical activation becoming less diffuse and more focal over time. However, while adult learning studies examine changes within subjects, developmental findings have been based on cross-sectional samples and even comparisons across studies. Here, we used functional MRI in children to test directly for shifts in cortical activity during performance of a cognitive control task, in a combined longitudinal and cross-sectional study. Our longitudinal findings, relative to our cross-sectional ones, show, attenuated activation in dorsolateral prefrontal cortical areas, paralleled by increased focal activation in ventral prefrontal regions related to task performance.