Staphylococcus aureus interactions with the endothelium -: The role of bacterial "Secretable Expanded Repertoire Adhesive Molecules" (SERAM) in disturbing host defense systems
Staphylococcus aureus interactions with the endothelium -: The role of bacterial "Secretable Expanded Repertoire Adhesive Molecules" (SERAM) in disturbing host defense systems
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DOI：
10.1160/th05-05-0306
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发表时间：
2005-08-01
影响因子：
6.7
通讯作者：
Herrmann, M
中科院分区：
文献类型：
--
作者：
Chavakis, T;Wiechmann, K;Herrmann, M
金黄色葡萄球菌感染的血管内表现通常与严重的，有时是灾难性的疾病有关。许多宿主因子有助于金黄色葡萄球菌的内皮性，包括内皮下基质蛋白、内皮细胞受体和血小板，它们与金黄色葡萄球菌细胞壁粘附素（如纤维连接蛋白结合蛋白）结合在一起。最近，最初通过与宿主蛋白和配体的结合功能确定的葡萄球菌分泌因子的作用在这方面得到了重新评价。其中，无明显同源性的细菌蛋白，凝血酶（Coa）、细胞外纤维蛋白原结合蛋白（Efb）、细胞外基质结合蛋白（Emp）或细胞外粘附蛋白（Eap）是与血管内疾病相关最突出的蛋白。新发现的与宿主成分的相互作用可能对免疫调节和伤口愈合有深远的影响，这在本文中进行了总结，并认为这些分子在急性和慢性血管内和血管外葡萄球菌疾病中起着重要作用。进一步研究这些“可分泌的扩展库粘附分子”（SERAM）的复杂功能作用，不仅有助于增加我们对金黄色葡萄球菌感染发病机制的理解，而且可以为预防或治疗策略指定新的靶点。
The intravascular manifestation of Staphylococcus aureus infection is often associated with a severe, and sometimes catastrophic disease. Many host factors contribute to endothelial tropism of S. aureus including subendothelial matrix proteins, endothelial cell receptors, and platelets that are engaged together with S. aureus cell wall adhesins such as the fibronectin binding proteins. Recently, the role of secreted staphylococcal factors that were initially identified by virtue of their binding function with host proteins and ligands, has been reappraised in this regard. Among these, bacterial proteins without significant homology among each other, coagulase (Coa), the extracellular fibrinogen binding protein (Efb), the extracellular matrix binding protein (Emp), or the extracellular adhesive protein (Eap), are the most prominent ones to be associated with endovascular disease. Newly discovered interactions with host components may account for profound effects on immunmodulation and wound healing which are summarized in this short review and which ascribe an important role of these molecules in acute and chronic endo- and extravascular staphylococcal disease. Further research in the complex functional role of these "secretable expanded repertoire adhesive molecules" (SERAM) may not only help to increase our understanding in the pathogenesis of S. aureus infection but can specify novel targets for preventive or therapeutic strategies.