Acute phase reaction and acute phase proteins.
Acute phase reaction and acute phase proteins.
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DOI：
10.1631/jzus.2005.b1045
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发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
Koopmans, S J
中科院分区：
文献类型：
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作者：
Gruys, E;Toussaint, M J M;Koopmans, S J
综述了主要细胞因子参与的系统性急性期反应，肝脏代谢变化，阴性和阳性急性期蛋白（APPs）的功能和相关病理。APPs似乎是评估动物健康的合适分析物。虽然它们代表非特异性标记物作为生物效应反应物，但它们可用于评估营养缺陷和反应过程，特别是当阳性和阴性急性期变量结合在一个指数中时。当使用这种急性期指数将健康动物与患有某种疾病的动物分开时，获得的结果比使用单一分析物要好得多，并且可能达到统计上可接受的扑杀个体动物的结果。不幸的是，目前还没有一种便宜、全面和易于使用的系统可以同时评估血清或血液样品中的各种急性期蛋白质。蛋白质微阵列或液相微芯片技术可以满足这一需求；并且允许在同一小体积样品中同时分析许多分析物，并能够整合来自系统反应性和营养与疾病特定变量的信息。应用这种技术不仅可以帮助解决各国畜牧业的健康问题，还可以帮助解决人口的健康问题。
A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.