Experimental septic shock--effects of corticosteroids.
Experimental septic shock--effects of corticosteroids.
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实验性感染性休克——皮质类固醇的作用。
DOI：
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发表时间：
1982
期刊：
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通讯作者：
R. Söderberg
中科院分区：
文献类型：
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作者：
J. Ottosson;Å. Brandberg;B. Erikson;L. Hedman;I. Dawidson;R. Söderberg
进行这些研究是为了评估皮质类固醇在实验性脓毒性休克模型中的最佳效果，考虑到治疗机构的时间和皮质类固醇（地塞米松和甲泼尼龙）的剂量。通过腹膜内注射5 × 108活大肠杆菌/100 g体重诱导感染性休克。在注射细菌前和注射细菌后4 h测量红细胞压积。连续记录24 h的存活时间，然后每天记录7天。在未处理的对照动物中，死亡率与4 h时的红细胞压积增加相关。存活的大鼠没有增加他们的红细胞压积，但非幸存者。未处理大鼠的存活时间为9.2 +/- 0.2 h（SEM）。皮质类固醇显着增加生存时间时，给予间接。然而，这种效果，随着时间的推移呈线性下降时，给予地塞米松细菌注射后8小时。地塞米松（3-96 mg/kg）和甲基强的松龙（19-225 mg/kg）可显著延长存活时间。22%（73/329）的皮质类固醇治疗动物的寿命超过24小时，而对照组为14%（19/135）。该差异具有临界显著性（P = 0.05）。
These studies were undertaken to evaluate the optimal effects of corticosteroids in an experimental septic shock model, with regard to time of therapy institution and the dose of corticosteroids (dexamethasone and methylprednisolone). Septic shock was induced by intraperitoneal injection of 5 x 10(8) live E coli bacteria/100 g body weight. Hematocrit was measured before and 4 h after injection of bacteria. Survival time was recorded continuously for 24 h and then daily for 7 days. Mortality rate correlated with hematocrit increase at 4 h in untreated control animals. Surviving rats did not increase their hematocrit, but nonsurvivors did. Survival time in untreated rats was 9.2 +/- 0.2 h (SEM). Corticosteroids significantly increased survival time when given prophylactically. This effect, however, decreased linearly with time when dexamethasone was given up to 8 h after bacteria injection. Dexamethasone (3-96 mg/kg) and methylprednisolone (19-225 mg/kg) significantly prolonged survival time. Twenty-two percent (73/329) of corticosteroid-treated animals lived longer than 24 h compared to 14% (19/135) of the controls. This difference was of borderline significance (P = 0.05).