Big Data, Big Opportunities, and Big Challenges.
Big Data, Big Opportunities, and Big Challenges.
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DOI：
10.1038/jidsymp.2015.38
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发表时间：
2015-11-01
期刊：
影响因子：
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通讯作者：
Frelinger, Jeffrey A
中科院分区：
文献类型：
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作者：
Frelinger, Jeffrey A
高通量分析已经开始彻底改变现代生物学和医学。廉价的下一代测序技术（NGS）的出现使人们有可能以前所未有的方式询问细胞和人群。虽然这使我们能够研究遗传学，基因表达和微生物组的影响，但仍然存在实际和概念上的挑战。这些包括数据处理、存储和统计分析，以及异质细胞群体分析的固有问题。
High-throughput assays have begun to revolutionize modern biology and medicine. The advent of cheap next-generation sequencing (NGS) has made it possible to interrogate cells and human populations as never before. Although this has allowed us to investigate the genetics, gene expression, and impacts of the microbiome, there remain both practical and conceptual challenges. These include data handling, storage, and statistical analysis, as well as an inherent problem of the analysis of heterogeneous cell populations.