Changes in heart rate and heart rate variability over time in middle-aged men and women in the general population (from the Whitehall II Cohort Study)
Changes in heart rate and heart rate variability over time in middle-aged men and women in the general population (from the Whitehall II Cohort Study)
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DOI：
10.1016/j.amjcard.2007.03.056
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发表时间：
2007-08-01
影响因子：
2.8
通讯作者：
Marmot, Michael
中科院分区：
文献类型：
--
作者：
Britton, Annie;Shipley, Martin;Marmot, Michael
先前的横断面研究表明，心率 (HR) 和心率变异性 (HRV) 受到多种行为、生物和社会心理因素的影响。很少有纵向研究能够在个体水平上分析 HRV 随时间的变化。本研究旨在描述一般人群中 HR 和 HRV 的变化，并确定随访时 HR 和 HRV 的预测因子。从 1997 年到 2004 年，英国 Whitehall 11 队列研究的 1,999 名参与者（29% 为女性）进行了 2 次心脏自主功能测量（测量之间的平均时间为 5.47 年，范围为 4.07 至 6.93）。第一次测量时的平均 +/- SD 年龄为 55.6 +/- 6.0 岁。在基线时，男性比女性表现出更高的低频功率，这表明他们可能具有更高的交感神经活动。相反，女性的高频功率较高，表明副交感神经张力较高。在 5 年的随访期内，男性和女性的 ID HR 均有所下降。男性的 HRV 在时间和频率维度上有所降低，而女性的 HRV 则有所增加。总之，随访时 HRV 功能和 HR 处于不利四分位的概率与基线运动、体重指数、胆固醇和血压有关。 (c) 2007 Elsevier Inc. 保留所有权利。
Previous cross-sectional studies have shown that heart rate (HR) and HR variability (HRV) are influenced by several behavioral, biologic, and psychosocial factors. There are very few longitudinal studies that enable analyses of changes in HRV over time at an individual level. This study aimed to describe changes in HR and HRV in a general population setting and to determine predictors of HR and HRV at follow-up. From 1997 to 2004, 1,999 participants (29% women) in the United Kingdom Whitehall 11 Cohort Study had 2 measurements of cardiac autonomic function (mean time between measurements 5.47 years, range 4.07 to 6.93). The mean +/- SD age at the first measurement was 55.6 +/- 6.0 years. At baseline, men showed higher low-frequency power than women, suggesting that they may have higher sympathetic activity. Conversely, women had higher high-frequency power, indicating higher parasympathetic tone. Over the 5-year follow-up period, men and women had decreases id HR. Men had reductions in HRV in time and frequency dimensions., whereas women showed increases in HRV. In conclusion, the probability of being in the adverse quartile of HRV function and HR at follow-up was related to baseline exercise, body mass index, cholesterol, and blood pressure. (c) 2007 Elsevier Inc. All rights reserved.