Invertebrate immunity and the limits of mechanistic immunology
Invertebrate immunity and the limits of mechanistic immunology
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DOI：
10.1038/ni1219
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发表时间：
2005-07-01
影响因子：
30.5
通讯作者：
Read, AF
中科院分区：
文献类型：
--
作者：
Little, TJ;Hultmark, D;Read, AF
在阐明无脊椎动物免疫的分子机制方面正在取得迅速进展。这种对分子的搜索冒着错过重要现象的风险。在脊椎动物中，获得性保护和病原体特异性反应早在相关机制阐明之前就已得到实验证明。如果没有类似的实验，机制驱动的工作可能无法证明无脊椎动物免疫的全部丰富性。
Rapid progress is being made in elucidating the molecular mechanisms involved in invertebrate immunity. This search for molecules runs the risk of missing important phenomena. In vertebrates, acquired protection and pathogen-specific responses were demonstrated experimentally long before the mechanisms responsible were elucidated. Without analogous experiments, mechanism-driven work may not demonstrate the full richness of invertebrate immunity.