Photoresponsive Cross‐linked Polymeric Particles for Phototriggered Burst Release
Photoresponsive Cross‐linked Polymeric Particles for Phototriggered Burst Release
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DOI：
10.1111/php.12038
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发表时间：
2013-05
影响因子：
3.3
通讯作者：
Zhen Wang;Li-li Yu;Cong Lv;Peng Wang;Ye Chen;Xinjing Tang
中科院分区：
文献类型：
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作者：
Zhen Wang;Li-li Yu;Cong Lv;Peng Wang;Ye Chen;Xinjing Tang
通过微乳液聚合，我们合成了一系列具有光稳定性单体和交联剂的交联光响应聚合物颗粒。这些颗粒在黑暗中非常稳定，而光照射导致颗粒破裂，根据尼罗红荧光，包封内容物的有效释放率高达95%。通过荧光光谱、扫描电镜和比色法对粒子体系的光开关进行了验证。双醋酸荧光素负载颗粒证实了RAW264.7细胞对颗粒的摄取和触发释放。
We synthesized a series of cross‐linked photoresponsive polymeric particles with photolabile monomers and cross‐linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles.