Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users
Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users
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DOI：
10.1371/journal.pone.0218334
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发表时间：
2019-06-21
期刊：
影响因子：
3.7
通讯作者：
Grassi-Oliveira, Rodrigo
中科院分区：
文献类型：
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作者：
Sanvicente-Vieira, Breno;Rovaris, Diego Luiz;Grassi-Oliveira, Rodrigo
快克可卡因使用障碍（CUD）与性别差异有关。本研究旨在比较男性和女性CUD患者药物使用的严重程度和其他负面相关结果的严重程度。对1344例快克可卡因使用障碍（CUD）住院患者（男798例，女546例）进行详细的多维临床评估，包括成瘾程度和创伤暴露。线性回归预测，女性吸毒严重程度较高（beta = 0.273, p < 0.001），在儿童保育问题（beta = 0.321）、犯罪参与（beta = 0.108）、工作相关问题（beta = 0.281）和社会支持障碍（beta = 0.142）等领域存在更多问题，均p < 0.001。男性的酒精问题预计更高（β = -0.206, P < 0.001）。女性患其他精神疾病的比例更高，尤其是创伤和压力相关疾病（OR: 3.206, CI: 2.22, 4.61）。在创伤史和艾滋病毒感染率方面也出现了重要的性别差异。在面临早期禁欲的女性中，CUD有更严重的临床表现。CUD过程中的性别差异表明需要考虑针对性别的干预和研究。
Crack cocaine use disorder (CUD) has been related to sex differences. This work aimed to compare the severity of drug use and the severity of other negative related outcomes in males and females with CUD. A total of 1344 inpatients (798 males and 546 females) with crack cocaine use disorder (CUD) were evaluated by a detailed multidimensional clinical assessment, including addiction severity and trauma exposure. Linear regression predicted higher drug use severity (beta = 0.273, p < 0.001) and more problems in domains related to childcare issues (beta = 0.321), criminal involvement (beta = 0.108), work-related problems (beta = 0.281) and social support impairments (beta = 0.142) for females, all with p < 0.001. Alcohol problems were predicted to be higher in males (beta = -0.206, P < 0.001). Females had higher rates of other mental disorders, particularly trauma and stress-related disorders (OR: 3.206, CI: 2.22, 4.61). Important sex differences also emerged in trauma history and HIV infection prevalence. CUD has a more severe clinical presentation among females facing early abstinence. Sex differences in the CUD course indicate the need for consideration of sex-specific interventions and research.